2''-O-Rhamnosylicariside II

2''-O-Rhamnosylicariside II
Product Name 2''-O-Rhamnosylicariside II
CAS No.: 135293-13-9
Catalog No.: CFN92551
Molecular Formula: C33H40O14
Molecular Weight: 660.7 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Epimedium brevicornu
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $388/10mg
2″-O-Rhamnosylicariside II shows potent antioxidant activity, with IC50 values of 11.5 ug/mL and 90.5 uM. It shows potent inhibitory activities on osteoclast-like cell formation at a concentration of 2 uM without toxic effects.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Inhibitory effect of constituents of Bu-Shen-Jian-Gu-Tang on osteoclast-like cell formation[Reference: WebLink]
    The constituents of Bu-Shen-Jian-Gu-Tang and their inhibitory activities on osteoclast-Iike cell formation were investigated. Bu-Shen-Jian-Gu-Tang was fractionated by a Diaion HP-20 column with EtOH-H_2O, and the 60% and 90% EtOH-H_20 fractions showed more potent inhibitory activities on osteoclast-like cell formation and bone resorption.
    METHODS AND RESULTS:
    Chemical investigation of these two fractions resulted in the isolation of 11 compounds, for which the structures were elucidated based on spectroscopic analysis and chemical reactions. The inhibitory activities of the isolated compounds on osteoclast-like cell formation were evaluated. Among the eleven compounds, icariin (1), icarisid II (2), 2''-O-Rhamnosylicariside II (3), kaempferol (8), chikusetsusaponin IVa (10) and chikusetsusaponin V (11) showed potent inhibitory activities at a concentration of 2 μM without toxic effects.
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    The preventive effect of Bu-Shen-Jian-Gu-Tang on bone loss may be due to the inhibitory activities of these compounds.
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    CONCLUSIONS:
    Compounds 1 and 4 showed potent antioxidant activity, with IC50 values of 19.7 and 11.5 μg/mL and 88.2 and 90.5 μM, respectively.
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