Gramodendrine
Gramodendrine and ammodendrine are moderately potent (300 mg/kg, ip) in reducing spontaneous motor activity (30% of control) and in causing central nervous system depression (50% of control). spect.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Agricultural & Food Chemistry, 1985,33 (5) :909-912.
Identification of toxic alkaloids from the calcaratus subspecies of Lupinus arbustus.[Reference:
WebLink]
A recent chemical study of the previously uninvestigated Lupinus arbustus subspecies calcaratus resulted in the isolation and characterization of the novel bipiperidyl-indole alkaloid Gramodendrine.
METHODS AND RESULTS:
The present study describes the identification of three additional structurally diverse alkaloids from the title plant.
These include the quinolizidine base lusitanine, the piperidine derivative ammodendrine, and the indole alkylamine gramine. The total alkaloid fraction as well as the first three of the above individual alkaloids were tested for gross locomotor activity and for rotorod performance in mice.
CONCLUSIONS:
Pharmacologic data indicated that Gramodendrine and ammodendrine were moderately potent (300 mg/kg, ip) in reducing spontaneous motor activity (30% of control) and in causing central nervous system depression (50% of control).
Phytochemistry,1982,21(6):1415-1417.
Gramodendrine, a bipiperidyl-indole alkaloid from Lupinus arbustus subsp. calcara tus[Reference:
WebLink]
METHODS AND RESULTS:
A new bipiperidyl-indole alkaloid, Gramodendrine, was isolated from Lupinus arbustus subsp. calcaratus. Its structure was determined from spect.
