Gramodendrine

Journal of Agricultural & Food Chemistry, 1985,33 (5) :909-912.

Identification of toxic alkaloids from the calcaratus subspecies of Lupinus arbustus.[Reference: WebLink]

A recent chemical study of the previously uninvestigated Lupinus arbustus subspecies calcaratus resulted in the isolation and characterization of the novel bipiperidyl-indole alkaloid Gramodendrine.
METHODS AND RESULTS:
The present study describes the identification of three additional structurally diverse alkaloids from the title plant. These include the quinolizidine base lusitanine, the piperidine derivative ammodendrine, and the indole alkylamine gramine. The total alkaloid fraction as well as the first three of the above individual alkaloids were tested for gross locomotor activity and for rotorod performance in mice.
CONCLUSIONS:
Pharmacologic data indicated that Gramodendrine and ammodendrine were moderately potent (300 mg/kg, ip) in reducing spontaneous motor activity (30% of control) and in causing central nervous system depression (50% of control).

Phytochemistry,1982,21(6):1415-1417.

Gramodendrine, a bipiperidyl-indole alkaloid from Lupinus arbustus subsp. calcara tus[Reference: WebLink]

METHODS AND RESULTS:
A new bipiperidyl-indole alkaloid, Gramodendrine, was isolated from Lupinus arbustus subsp. calcaratus. Its structure was determined from spect.