Goshonoside F5

Goshonoside F5
Product Name Goshonoside F5
CAS No.: 90851-28-8
Catalog No.: CFN89238
Molecular Formula: C32H54O13
Molecular Weight: 646.77 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: NO | PGE | NOS | COX | p65 | NF-kB | IkB | JNK | TNF-α | p38MAPK | IKK
Source: The leaves of Japanese R. chingii.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Natural Product Communications2020, doi: 10.1177.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Molecules.2019, 24(24),4583
  • Appl. Sci.2023, 13(17), 9653.
  • Antioxidants (Basel).2024, 13(8):951.
  • Journal of Phytopathology2021, 169,Issue11-12.
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • BMB Rep.2018, 51(5):249-254
  • J Anal Toxicol.2021, bkab015.
  • Int J Med Sci.2021, 18(10):2155-2161.
  • ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside

    Catalog No: CFN96078
    CAS No: 1245636-01-4
    Price: Inquiry(manager@chemfaces.com)
    Goshonoside F1

    Catalog No: CFN89220
    CAS No: 90851-24-4
    Price: Inquiry(manager@chemfaces.com)
    Goshonoside F5

    Catalog No: CFN89238
    CAS No: 90851-28-8
    Price: Inquiry(manager@chemfaces.com)
    Agatholal

    Catalog No: CFN98497
    CAS No: 3650-31-5
    Price: Inquiry(manager@chemfaces.com)
    Imbricatolic acid

    Catalog No: CFN97164
    CAS No: 6832-60-6
    Price: Inquiry(manager@chemfaces.com)
    Isocupressic acid

    Catalog No: CFN99882
    CAS No: 1909-91-7
    Price: Inquiry(manager@chemfaces.com)
    Acetylisocupressic acid

    Catalog No: CFN98880
    CAS No: 52992-82-2
    Price: Inquiry(manager@chemfaces.com)
    Scoparinol

    Catalog No: CFN99397
    CAS No: 130838-00-5
    Price: Inquiry(manager@chemfaces.com)
    Agathadiol diacetate

    Catalog No: CFN98250
    CAS No: 24022-13-7
    Price: Inquiry(manager@chemfaces.com)
    ent-Labda-8(17),13E-diene-3beta,15,18-triol

    Catalog No: CFN89384
    CAS No: 90851-50-6
    Price: Inquiry(manager@chemfaces.com)
    Int Immunopharmacol. 2015 Feb;24(2):182-190.
    Suppression of nuclear factor-kappa B and mitogen-activated protein kinase signalling pathways by goshonoside-F5 extracted from Rubi Fructus.[Pubmed: 25523460 ]
    Rubi Fructus, a traditional Chinese medicine, was considered as an anti-inflammatory agent in folk medicine.
    METHODS AND RESULTS:
    In the present study, we investigated the signalling pathways involved in the anti-inflammatory effects of Goshonoside F5 (GF5), isolated from Rubi Fructus, in peritoneal macrophages and examined its therapeutic effect in a mouse endotoxic shock model. GF5 decreased NO and PGE2 production in LPS-stimulated macrophages (IC50=3.84 and 3.16μM). This effect involved the suppression of NOS-2 and COX-2 gene expression at the transcriptional level. Examination of the effects of GF5 on NF-κB signalling demonstrated that it inhibits the phosphorylation of IκB-α and IκB-β, blocking their degradation and the nuclear translocation of the NF-κB p65 subunit. Moreover, inhibition of MAPK signalling was also observed, and phosphorylation of p38 and JNK was suppressed in the presence of GF5. Inflammatory cytokines, including IL-6 and TNF-α, were down-regulated by this compound after activation with LPS (IC50=17.04 and 4.09μM). Additionally, GF5 (30 and 90mg/kg, i.p.) significantly reduced the circulating cytokine levels (IL-6 and TNF-α) and increased survival in a mouse model of endotoxemia.
    CONCLUSIONS:
    These results show that GF5 significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. Our results provide a strong pharmacological basis for further understanding the potential therapeutic role of GF5 in inflammatory disease and shed new light on the bioactivity of ent-labdane diterpene glucoside.
    Chem Pharm Bull (Tokyo). 1987 Jul;35(7):3021-4.
    Diterpene glycosides from leaves of Chinese Rubus chingii and fruits of R. suavissimus, and identification of the source plant of the Chinese folk medicine [Reference: WebLink]

    METHODS AND RESULTS:
    Five diterpene glycosides, goshonoside F1, goshonoside F2, goshonoside F3, goshonoside F4 and Goshonoside F5(4-8), which are characteristic of the leaves of Japanese R. chingii(Gosho-ichigo), were isolated from the leaves of Chinese R. chingii(Zhan-yei fu-pen-zi). This proved the chemotaxonomical identity of the plants.
    CONCLUSIONS:
    Compound 8 was also detected in commercial Chinese folk medicine, Fu-pen-xi, indicating that the source plant of this drug is R. chingii. Rubusoside (1), which is the sweet diterpene gfycoside of the leaves of R. suavissimus(Chinese name: Gan-yei xuen-gou-zi), was also identified in fruits of the plant.
    Epimedin K

    Catalog No: CFN95019
    CAS No: 174286-13-6
    Price: $288/5mg
    3,4-O-dimethylcedrusin

    Catalog No: CFN95026
    CAS No: 166021-14-3
    Price: $388/10mg
    Lucidumol A

    Catalog No: CFN95059
    CAS No: 217476-73-8
    Price: $318/5mg
    Parvisoflavanone

    Catalog No: CFN95077
    CAS No: 49776-79-6
    Price: $413/5mg
    Isocarlinoside

    Catalog No: CFN95092
    CAS No: 83151-90-0
    Price: $318/5mg
    Pueroside C

    Catalog No: CFN95156
    CAS No: 112343-16-5
    Price: $368/5mg
    (1,5E,11E)-tridecatriene-7,9-diyne-3,4-diacetate

    Catalog No: CFN95161
    CAS No: 201012-14-8
    Price: $318/10mg
    Quasipanaxatriol

    Catalog No: CFN95248
    CAS No: 171903-78-9
    Price: $413/5mg
    Oxytroflavoside D

    Catalog No: CFN95491
    CAS No: 1391144-83-4
    Price: $318/10mg
    N-Demethylfordianoside

    Catalog No: CFN95589
    CAS No: N/A
    Price: $318/10mg