Gomisin L1
(-)-Gomisin L1 induces G2/M arrest and apoptosis in human ovarian cancer cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
United States Patent Application2020, 20200038363
Int J Nanomedicine.2024, 19:1683-1697.
Phytother Res.2022, 35844057.
The Japan Society for Analytical Chemistry2018, 67(4):201-206
BMC Complement Altern Med.2019, 19(1):367
Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
VNU J of Science: Med.&Pharm. Sci.2023, 39(1):20-29.
Molecules.2016, 21(6)
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Front. Pharmacol.2022, 901563.
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International Journal of Molecular Medicine, 2015, 36:S57-S57.
(-)-Gomisin L1 isolated from Schisandra Chinensis fruit induces G2/M arrest and apoptosis in human ovarian cancer cells[Reference:
WebLink]
(-)-Gomisin L1 isolated from Schisandra Chinensis fruit induces G2/M arrest and apoptosis in human ovarian cancer cells.
Chemical & Pharmaceutical Bulletin, 1982, 30(1):132-139
The Constituents of Schizandra chinensis Baill. X. The Structures of .GAMMA.-schizandrin and four new lignans,(-)-gomisins L1 and L2,(.+-.)-gomisin M1 and (+)-gomisin M2.[Reference:
WebLink]
METHODS AND RESULTS:
Four new dibenzocyclooctadiene lignans, named (-)-Gomisin L1 (6) and (-)-gomisin L2 (7), (±)-gomisin M1 (8) and (+)-gomisin M2 (9), were isolated from the fruits of Schizandra chinensis BAILL. (Schizandraceae). Their absolute structures were elucidated by means of chemical and spectral studies.
CONCLUSIONS:
The stereostructure of γ-schizandrin (1, dl-form), the plane structure of which had already been suggested by Kochetkov et al. and Liu et al., was also elucidated on the basis of chemical and spectral studies.
