Gitoxin
Gitoxin may offer a potential treatment for drug resistant NSCLC.It inhibited the phosphorylation of Erk1/2 in a dosage and time dependent way.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Basic & Clinical Medicine, 2013.
Inhibitory effect of gitoxin on non-small cell lung cancer with gefitinib resistance.[Reference:
WebLink]
To evaluate the inhibitory effect of Gitoxin on non small cell lung cancer with drug-resistance in vitro and in vivo and to explore the underlying molecular mechanism.
METHODS AND RESULTS:
Survival and apoptosis rates of H1975 were measured by MTS assay and flow cytometry respectively after Gitoxin and gefitinib treatments.Tumor volumes of Gitoxin treated xenograft nude mice were calculated by measuring the lengths and widths of these tumors.The phosphorylation of Erk1/2 was analyzed by Western blot. Gitoxin inhibited the growth of H1975 and induced its apoptosis more effectively than gefitinib.It also inhibited growth of transplanted tumors in nude mice.In addition,Gitoxin inhibited the phosphorylation of Erk1/2 in a dosage and time dependent way.
CONCLUSIONS:
Gitoxin may offer a potential treatment for drug resistant NSCLC.
