Ginsenoside F4

Ginsenoside F4
Product Name Ginsenoside F4
CAS No.: 181225-33-2
Catalog No.: CFN90757
Molecular Formula: C42H70O12
Molecular Weight: 767.0 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: Bcl-2/Bax | MMP(e.g.TIMP) | IL Receptor | p38MAPK
Source: The roots of Panax ginseng C. A. Mey.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $318/10mg
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression. Ginsenoside F4 also has strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Phytomedicine. 2017 Jan 15;
  • Pharmacogn Mag.2015 Jul-Sep.
  • J Drug Target.2016 Feb 24:1-28.
  • Afr. J. Agric. Res. 27 January 2017
  • BMC Complement Altern Med.2014 Sep 23;14:352.
  • Research on Crops.2017, Issue : 3
  • JPCMarch 16, 2017
  • Int J Mol Sci. 2017 May 11;
  • Gorana Nedin Rankovi?2017 Jan 15
  • Evid Based Complement Alternat Med. 2016 May 24;
  • Notoginsenoside Fc

    Catalog No: CFN93283
    CAS No: 88122-52-5
    Price: $198/20mg
    Ginsenoside Rb1

    Catalog No: CFN99964
    CAS No: 41753-43-9
    Price: $40/20mg
    Notoginsenoside Fa

    Catalog No: CFN93284
    CAS No: 88100-04-3
    Price: $158/20mg
    Notoginsenoside R4

    Catalog No: CFN91142
    CAS No: 87741-77-3
    Price: $238/5mg
    Ginsenoside Ra2

    Catalog No: CFN93293
    CAS No: 83459-42-1
    Price: $268/5mg
    Notoginsenoside Fe

    Catalog No: CFN93282
    CAS No: 88105-29-7
    Price: $218/20mg
    Ginsenoside Rc

    Catalog No: CFN99973
    CAS No: 11021-14-0
    Price: $100/20mg
    Ginsenoside F1

    Catalog No: CFN99754
    CAS No: 53963-43-2
    Price: $148/20mg
    Ginsenoside F3

    Catalog No: CFN99978
    CAS No: 62025-50-7
    Price: $138/10mg
    Ginsenoside F5

    Catalog No: CFN95034
    CAS No: 189513-26-6
    Price: $298/20mg
    Nat Prod Res. 2013;27(24):2351-4.
    The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells.[Pubmed: 23962295]

    METHODS AND RESULTS:
    In this study, the inhibitory and apoptosis-inducing effect of Ginsenoside F4 (GF4) from steamed notoginseng was investigated by using human lymphocytoma Jurkat (JK) cell. Cell Counting Kit-8 method was then used to assess the anti-proliferative effect of GF4, and Western blotting was run to detect the expression level of two apoptosis-related proteins including Bax and the Bcl-2. The results suggested that GF4 can effectively inhibit the proliferation of the cells, and Bax expression increased gradually, but Bcl-2 expression reduced with the increase of GF4 concentration.
    CONCLUSIONS:
    In conclusion, GF4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. The mechanism of action could be related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression by GF4.
    Eur J Pharmacol. 2014 Feb 5;724:145-51.
    Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation.[Pubmed: 24384406]
    Among the mammalian matrix metalloproteinases (MMPs), MMP-1, -3 and -13 are collagenases. Particularly, MMP-13 is important for the degradation of major collagens in cartilage under certain pathological conditions such as osteoarthritis.
    METHODS AND RESULTS:
    To establish a potential therapeutic strategy for cartilage degradation disorders, the effects of 11 ginseng saponins (ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rg5, Rk1 and F4) on MMP-13 induction were examined in a human chondrocyte cell line, SW1353. Among these, several saponins including ginsenoside Rc, Rd, Rf, Rg3 and F4 were found to inhibit MMP-13 expression in IL-1β-treated SW1353 cells at non-cytotoxic concentrations (1-50 μM). The most prominent inhibitors were ginsenosides F4 and Rg3. Ginsenoside F4 inhibited MMP-13 expression 33.5% (P<0.05), 57.9% (P<0.01) and 90.0% (P<0.01) at 10, 30 and 50 μM, respectively. Significantly, Ginsenoside F4 was found to strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways (86.6 and 100.0% inhibition at 30 and 50 μM, P<0.01). The MMP-13 inhibitory effect was also supported by the finding that ginsenosides F4 and Rg3 reduced glycosaminoglycan release from IL-1α-treated rabbit joint cartilage culture to some degree. Taken together, these results indicate that several ginsenosides inhibit MMP-13 expression in IL-1β-treated chondrocytes. Ginsenoside F4 and Rg3 blocked cartilage breakdown in rabbit cartilage tissue culture.
    CONCLUSIONS:
    Thus, it is suggested that certain ginsenosides have therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues such as those found in patients with arthritic disorders.
    6',7'-Dihydroxybergamottin

    Catalog No: CFN98307
    CAS No: 264234-05-1
    Price: $438/10mg
    Astragalin

    Catalog No: CFN98733
    CAS No: 480-10-4
    Price: $138/20mg
    Sagittatoside B

    Catalog No: CFN90211
    CAS No: 118525-36-3
    Price: $318/5mg
    Ganoderic acid C6

    Catalog No: CFN92290
    CAS No: 105742-76-5
    Price: $368/10mg
    Chebulagic acid

    Catalog No: CFN92295
    CAS No: 23094-71-5
    Price: Inquiry(manager@chemfaces.com)
    Aristolochic acid D

    Catalog No: CFN90783
    CAS No: 17413-38-6
    Price: $348/10mg
    Methylnissolin

    Catalog No: CFN90838
    CAS No: 733-40-4
    Price: $388/10mg
    7-Neohesperidosides

    Catalog No: CFN95018
    CAS No: 28383-41-7
    Price: $288/5mg
    Physalin O

    Catalog No: CFN95097
    CAS No: 120849-18-5
    Price: $413/5mg
    Asiaticoside B

    Catalog No: CFN95124
    CAS No: 125265-68-1
    Price: $198/20mg