Neolinine

Planta Med. 2011 Mar;77(4):368-73.

Diterpene alkaloids from Aconitum anthora and assessment of the hERG-inhibiting ability of Aconitum alkaloids.[Pubmed: 20862641 ]

A new norditerpene alkaloid, 10-hydroxy-8- O-methyltalatizamine (1), was isolated from the whole plant of ACONITUM ANTHORA L. besides the known isotalatizidine (2) and hetisinone (3).
METHODS AND RESULTS:
The structures were determined by means of HR-ESI-MS, 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, resulting in complete 1H and 13C chemical shift assignments for 1- 3, and revision of some earlier 13C-NMR data. The effects of the isolated compounds, together with twenty-one other ACONITUM alkaloids with different skeletal types and substitution patterns, on hERG channels were studied by the whole-cell patch clamp technique, using the QPatch-16 automated patch clamp system.
CONCLUSIONS:
At 10 μM, aconitine, 14-benzoylaconine 8- O-palmitate, songoramine, gigactonine and Neolinine demonstrated significant hERG K+ channel inhibition; all other compounds exerted only low (6-21%) inhibitory activity.

Chinese Traditional & Herbal Drugs,1996,27(1):5-8.

Studies on the Diterpenoid Alkaloids of Yiyulongwutou (Aconitum pseudostapfianum)[Reference: WebLink]

METHODS AND RESULTS:
From the roots of Aconitum pseudostapfianum W. T. Warig,ten diterpenoid alkaloids were isolated and identified as 14-benzoyl-8-O-methylaconine (Ⅰ ),aconitine(Ⅱ),deoxyaconitine(Ⅲ),penduline (Ⅳ),yunaconitine (Ⅴ), Neolinine (Ⅵ), 15α-hydroxyneoline (Ⅶ), neoline (Ⅷ), talatisamine (Ⅸ)and aconosine (Ⅹ). I has not been previously found in nature.