Neolinine
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Med. 2011 Mar;77(4):368-73.
Diterpene alkaloids from Aconitum anthora and assessment of the hERG-inhibiting ability of Aconitum alkaloids.[Pubmed:
20862641 ]
A new norditerpene alkaloid, 10-hydroxy-8- O-methyltalatizamine (1), was isolated from the whole plant of ACONITUM ANTHORA L. besides the known isotalatizidine (2) and hetisinone (3).
METHODS AND RESULTS:
The structures were determined by means of HR-ESI-MS, 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, resulting in complete 1H and 13C chemical shift assignments for 1- 3, and revision of some earlier 13C-NMR data.
The effects of the isolated compounds, together with twenty-one other ACONITUM alkaloids with different skeletal types and substitution patterns, on hERG channels were studied by the whole-cell patch clamp technique, using the QPatch-16 automated patch clamp system.
CONCLUSIONS:
At 10 μM, aconitine, 14-benzoylaconine 8- O-palmitate, songoramine, gigactonine and Neolinine demonstrated significant hERG K+ channel inhibition; all other compounds exerted only low (6-21%) inhibitory activity.
Chinese Traditional & Herbal Drugs,1996,27(1):5-8.
Studies on the Diterpenoid Alkaloids of Yiyulongwutou (Aconitum pseudostapfianum)[Reference:
WebLink]
METHODS AND RESULTS:
From the roots of Aconitum pseudostapfianum W. T. Warig,ten diterpenoid alkaloids were isolated and identified as 14-benzoyl-8-O-methylaconine (Ⅰ ),aconitine(Ⅱ),deoxyaconitine(Ⅲ),penduline (Ⅳ),yunaconitine (Ⅴ), Neolinine (Ⅵ), 15α-hydroxyneoline (Ⅶ), neoline (Ⅷ), talatisamine (Ⅸ)and aconosine (Ⅹ). I has not been previously found in nature.
