Epoxylathyrol

Epoxylathyrol
Product Name Epoxylathyrol
CAS No.: 28649-60-7
Catalog No.: CFN98559
Molecular Formula: C20H30O5
Molecular Weight: 350.45 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The seeds of Euphorbia lathyris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
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    J. Nat. Prod., 2015, 78(9):2215-28.
    Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells[Pubmed: 26331763 ]

    METHODS AND RESULTS:
    Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells
    Tetrahedron,1975,31(4):305-9.
    Constituents of coper-spurge seed (lathyridis seed)—II : Novel acid-catalyzed reactions of epoxylathyrol[Reference: WebLink]

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    Reaction of Epoxylathyrol (1) with hydrochloric acid and other acids in THF led to simple fission of the epoxy ring and yielded the corresponding hydrin derivatives. When anhydrous methanol was used as the solvent, reaction of 1 with hydrochloric acid gave, as the major product, the novel macrocyclic trichloride (4) which has the jatrophane skeleton. Reaction with sulfuric acid afforded the transannular cyclization product (2) and methoxyhydrin (3). The structures of these compounds were deduced from spectral evidence.
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