Epoxylathyrol
Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J. Nat. Prod., 2015, 78(9):2215-28.
Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells[Pubmed:
26331763 ]
METHODS AND RESULTS:
Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells
Tetrahedron,1975,31(4):305-9.
Constituents of coper-spurge seed (lathyridis seed)—II : Novel acid-catalyzed reactions of epoxylathyrol[Reference:
WebLink]
METHODS AND RESULTS:
Reaction of Epoxylathyrol (1) with hydrochloric acid and other acids in THF led to simple fission of the epoxy ring and yielded the corresponding hydrin derivatives. When anhydrous methanol was used as the solvent, reaction of 1 with hydrochloric acid gave, as the major product, the novel macrocyclic trichloride (4) which has the jatrophane skeleton. Reaction with sulfuric acid afforded the transannular cyclization product (2) and methoxyhydrin (3). The structures of these compounds were deduced from spectral evidence.
Phytochemical Analysis, 2001,12(4):255-62
HPLC-UV and HPLC-positive-ESI-MS analysis of the diterpenoid fraction from caper spurge (Euphorbia lathyris) seed oil[Reference:
WebLink]
METHODS AND RESULTS:
Caper spurge (Euphorbia lathyris L.) seed oil contains a series of diterpenoids known as Euphorbia factors, or L-factors, L1–L9. They are esters of several polyols (lathyrol, Epoxylathyrol, hydroxylathyrol and ingenol) and account for about 3–5% of the oil. The percentage of ingenol-based L-factors is very low, less than 5% of the diterpenoid fraction, but some of them (factors L5 and L6) are responsible for the irritant and co-carcinogenic activities of the oil.
