Eleutheroside D
Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Current Topics in Nutraceutical Research2021, 19(1),p90-105.
Int J Mol Sci.2022, 23(23):14545.
Methods Protoc.2024, 7(6):95.
Toxins (Basel).2023, 15(3):231.
Oncology Letters2018, 4690-4696
Mol Biol Rep.2023, 50(5):4029-4038.
Clin Exp Pharmacol Physiol.2020, doi: 10.1111
Ethnomedicinal Plants for Drug Discovery2024, 491-509
LWT2020, 110397
Food Quality and Safety2018, 2:213-219
Related and Featured Products
Chinese General Practice, 2009, 12(4):292-4.
Protective Effect of Eleutheroside Preconditioning to Myocardial Ischemic Reperfusion Injury in Isolated Rats[Reference:
WebLink]
To investigate the protective effect of eleutherosid preconditioning to myocardial ischemic-reperfusion injury(IRI) in isolated rats and the dose-effect relationship between eleutheroside preconditioning and the myocardial protection.
METHODS AND RESULTS:
Male rat hearts,which were isolated and perfused with Langendorff apparatus,were randomly divided into 5 groups,6 in each.The isolated hearts were subjected to 25 min ischemia and then followed by 30 min reperfusion after 15min stabilization in control group(C).In the eleutheroside preconditioned groups(P1,P2,P3,P4),the hearts were perfused with eleutheroside(30 mg/kg,40 mg/kg,60 mg/kg and 80mg/kg,respectively) for 10 min before ischemia-reperfusion.Left ventricular developed pressure(LVDP),left ventricular end diastolic pressure(LVEDP),maximal rate of increase /decrease of left ventricular pressure(±dp/d tMax),and coronary blood flow(CF) were monitored continuously.And an arrhythmias score was used to quantify the arrhythmias during reperfusion.After reperfusing 30 min reperfusion,as compared with group C,① P2 and P3 groups might increase LVDP、+dp/dtMax and-dp/dtMax more significantly(P0.05);②P2 and P3 groups might raise CF more significantly(P0.01);③P2 and P3 groups had lower arrhythmia scores(P0.05).
CONCLUSIONS:
Eleutheroside preconditioning has a dose-effect on IRI of isolated rat hearts.
Evid Based Complement Alternat Med . 2013;2013:934183.
Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice[Pubmed:
23690865]
Abstract
Eleutheroside E (EE), a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory and protective effects in ischemia heart. However, it is unknown whether it ameliorates insulin resistance and reduces hyperglycemia in diabetes. This study investigated the effect of EE-containing ES extracts, as well as EE, on hyperglycemia and insulin resistance in db/db mice. EE increased the insulin-provoked glucose uptake in C2C12 myotubes. Moreover, EE improved TNF- α -induced suppression of glucose uptake in 3T3-L1 adipocytes. Five-week-old db/db mice were fed a diet consisting of ES extract or EE for 5 weeks. Both were effective in improving serum lipid profiles and significantly decreased blood glucose and serum insulin levels. ES and EE supplementation effectively attenuated HOMA-IR. Glucose tolerance and insulin tolerance tests showed that EE increased insulin sensitivity. Immunohistochemical staining indicated that ES and EE protected pancreatic alpha and beta cells from diabetic damage. In addition, ES and EE improved hepatic glucose metabolism by upregulating glycolysis and downregulating gluconeogenesis in obese type 2 diabetic mice. These data suggest that EE mediates the hyperglycemic effects of ES by regulating insulin signaling and glucose utilization. The beneficial effects of EE may provide an effective and powerful strategy to alleviate diabetes.
