Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
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Protective Effect of Eleutheroside Preconditioning to Myocardial Ischemic Reperfusion Injury in Isolated Rats[Reference: WebLink
To investigate the protective effect of eleutherosid preconditioning to myocardial ischemic-reperfusion injury(IRI) in isolated rats and the dose-effect relationship between eleutheroside preconditioning and the myocardial protection.
METHODS AND RESULTS:
Male rat hearts,which were isolated and perfused with Langendorff apparatus,were randomly divided into 5 groups,6 in each.The isolated hearts were subjected to 25 min ischemia and then followed by 30 min reperfusion after 15min stabilization in control group(C).In the eleutheroside preconditioned groups(P1,P2,P3,P4),the hearts were perfused with eleutheroside(30 mg/kg,40 mg/kg,60 mg/kg and 80mg/kg,respectively) for 10 min before ischemia-reperfusion.Left ventricular developed pressure(LVDP),left ventricular end diastolic pressure(LVEDP),maximal rate of increase /decrease of left ventricular pressure(±dp/d tMax),and coronary blood flow(CF) were monitored continuously.And an arrhythmias score was used to quantify the arrhythmias during reperfusion.After reperfusing 30 min reperfusion,as compared with group C,① P2 and P3 groups might increase LVDP、+dp/dtMax and-dp/dtMax more significantly(P0.05);②P2 and P3 groups might raise CF more significantly(P0.01);③P2 and P3 groups had lower arrhythmia scores(P0.05).
Eleutheroside preconditioning has a dose-effect on IRI of isolated rat hearts.