Dihydroajugapitin
Standard reference
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Separations2023, 10(4), 231.
Cell Biochem Funct.2018, 36(6):303-311
Phytomedicine.2018, 47:48-57
Front Pharmacol.2020, 11:251.
Org Biomol Chem.2017, 15(31):6483-6492
Chem Biol Interact.2019, 315:108910
Sci Rep. 2018, 1-9
Cell Chem Biol.2019, 26(1):27-34
Biol Pharm Bull.2020, 43(10):1534-1541.
Journal of Ginseng Research2024, 03.005.
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Chem Biodivers. 2004 Sep;1(9):1289-95.
Cholinesterase-inhibiting withanolides from Ajuga bracteosa.[Pubmed:
17191906]
METHODS AND RESULTS:
Three new withanolides, bracteosin A (= (22R)-5beta,6beta : 22,26-diepoxy-4beta,28-dihydroxy-3beta-methoxyergost-24-ene-1,26-dione; 1), bracteosin B (= (22R)-5beta,6beta : 22,26-diepoxy-4beta,28-dihydroxy-3beta-methoxy-1,26-dioxoergost-24-en-19-oic acid; 2), and bracteosin C (= (22R)-22,26-epoxy-4beta,6beta,27-trihydroxy-3beta-methoxyergost-24-ene-1,26-dione; 3), have been isolated from the whole plants of Ajuga bracteosa. Their structures were deduced by spectral analysis, including 1D- and 2D-NMR techniques. In addition, dihydroclerodin-1, clerodinin A, lupulin A, and Dihydroajugapitin have also been isolated for the first time from this species.
CONCLUSIONS:
Compounds 1-3 exhibited evident inhibitory potential against cholinesterase enzymes in a concentration-dependent fashion.
