Digitolutein
Digitolutein has inhibition on the growth of Plasmodium falciparum in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Separations2023, 10(4),255.
Biomed Pharmacother.2024, 175:116770.
Primary and Industrial.2018, 52(11)
Molecules.2016, 21(10)
Molecules.2020, 25(23):5556.
Biochem Biophys Res Commun.2017, 482(4):1095-1101
Drug Chem Toxicol.2020, 1-14.
PLoS One.2021, 16(9):e0257243.
Pharmaceuticals (Basel).2021, 14(10):1046.
J Cell Physiol.2020, 10.1002
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Planta Med., 1992, 58(6):533-4.
Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum.[Pubmed:
1484892 ]
METHODS AND RESULTS:
The effects of three compounds, Digitolutein (1), rubiadin 1-methyl ether (2) and damnacanthal (3) extracted from the stem bark and the roots of Morinda lucida Benth. on the growth of Plasmodium falciparum in vitro were investigated.
CONCLUSIONS:
The number of parasites (schizonts) decreased significantly in a dose-dependent manner, and 100% of inhibition was obtained with 30 to 40 micrograms of each compound tested. The IC50 values were calculated.
