Desoxyrhaponticin

Desoxyrhaponticin
Product Name Desoxyrhaponticin
CAS No.: 30197-14-9
Catalog No.: CFN90911
Molecular Formula: C21H24O8
Molecular Weight: 404.4 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: Fatty Acid Synthase
Source: The roots of Rumex obtusifolius L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $238/20mg
Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. Desoxyrhaponticin could be considered as a promising fatty acid synthase(FAS) inhibitor, it could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J-STAGE2015, 249-255
  • Tumour Biol.2015, 36(12):9385-93
  • Nat Plants.2016, 3:16205
  • Wageningen University & Research2018, January 2018
  • Phytomedicine.2015, 22(4):498-503
  • Nat Prod Sci.2014, 20(3):182-190
  • Molecules.2017, 22(12)
  • Front Pharmacol.2017, 8:673
  • Asian Journal of Chemistry2014, 26(8):2425
  • J Pharm Biomed Anal.2016, 129:50-59
  • Pterostilbene

    Catalog No: CFN90397
    CAS No: 537-42-8
    Price: $40/20mg
    3-Hydroxy-4',5-dimethoxystilbene

    Catalog No: CFN95199
    CAS No: 58436-29-6
    Price: $318/10mg
    Trimethoxystilbene

    Catalog No: CFN90874
    CAS No: 22255-22-7
    Price: $40/20mg
    3,5-Dimethoxy-3'-hydroxybibenzyl

    Catalog No: CFN89540
    CAS No: 168281-05-8
    Price: Inquiry(manager@chemfaces.com)
    Desoxyanisoin

    Catalog No: CFN90118
    CAS No: 120-44-5
    Price: Inquiry(manager@chemfaces.com)
    Arundinin

    Catalog No: CFN91179
    CAS No: 148225-38-1
    Price: $403/5mg
    Triacetylresveratrol

    Catalog No: CFN90895
    CAS No: 42206-94-0
    Price: $30/20mg
    Polydatin

    Catalog No: CFN99159
    CAS No: 27208-80-6
    Price: $30/20mg
    Pieceid-2''-O-gallate

    Catalog No: CFN95226
    CAS No: 105304-51-6
    Price: $318/10mg
    Dihydroresveratrol

    Catalog No: CFN98987
    CAS No: 58436-28-5
    Price: $288/20mg
    Food & Function, 2014 , 5 (2) :251-6.
    Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.[Pubmed: 24362821]
    Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Balf. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells.
    METHODS AND RESULTS:
    This study indicates that Desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time.
    CONCLUSIONS:
    Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer.
    J Pharmacol Exp Ther. 2007 Jan;320(1):38-46.
    Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies.[Pubmed: 17038511 ]
    Rhubarb extracts have been reported to improve oral glucose tolerance in diabetic animals.
    METHODS AND RESULTS:
    In the present study we have investigated the antidiabetic actions of Desoxyrhaponticin, a major stilbene in rhubarb, as a glucose uptake inhibitor. Desoxyrhaponticin was demonstrated to inhibit glucose uptake in rabbit intestinal membrane vesicles as well as in rat everted gut sleeves, with IC50 values of 148.3 and 30.9 microM, respectively. Kinetics studies revealed that Desoxyrhaponticin is a competitive inhibitor of glucose uptake in both systems. Moreover, Desoxyrhaponticin could reduce glucose uptake in the intestinal membrane vesicles of both normal and diabetic rats. In addition, glucose uptake in the renal membrane vesicles of both normal and diabetic rats was reduced by Desoxyrhaponticin. Under the inhibition of Desoxyrhaponticin, uptake of glucose in both the intestinal and renal membrane vesicles of the normal rats was no different from that of the diabetic rats. The IC50 values of the uptake inhibition in the renal membrane vesicles of normal and diabetic rats were 118.8 and 115.7 microM, respectively. In a type 2 diabetic animal model in which rats have been treated with streptozotocin at the neonatal stage, postprandial hyperglycemia was significantly suppressed by oral administration of this compound (300 mg/kg b.wt.).
    CONCLUSIONS:
    These results suggest that Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. The in vivo antidiabetic action of this compound can be explained, in part at least, by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney.
    Magnoloside A

    Catalog No: CFN99232
    CAS No: 113557-95-2
    Price: $318/5mg
    Ganoderenic acid D

    Catalog No: CFN90300
    CAS No: 100665-43-8
    Price: $476/10mg
    Gelidoside

    Catalog No: CFN89019
    CAS No: 128420-44-0
    Price: $288/10mg
    8-Hydroxypinoresinol diglucoside

    Catalog No: CFN95083
    CAS No: 112747-99-6
    Price: $318/5mg
    2-Cinnamoyl-1-galloylglucose

    Catalog No: CFN95098
    CAS No: 56994-83-3
    Price: $338/5mg
    6-O-(E)-Caffeoylglucopyranose

    Catalog No: CFN95105
    CAS No: 209797-79-5
    Price: $298/5mg
    Tessaric acid

    Catalog No: CFN95182
    CAS No: 58142-10-2
    Price: $318/5mg
    Spinacetin

    Catalog No: CFN95194
    CAS No: 3153-83-1
    Price: $318/5mg
    1,2-Epoxy-10(14)-furanogermacren-6-one

    Catalog No: CFN95214
    CAS No: 383368-24-9
    Price: $318/10mg
    Arisanschinin E

    Catalog No: CFN95221
    CAS No: 1333378-33-8
    Price: Inquiry(manager@chemfaces.com)