Clauszoline M
Clauszoline M shows a significant anti-tuberculosis activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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PLoS One.2022, 17(6):e0268505.
Pharmaceutics.2023, 15(6):1771.
Cancer Sci.2022, 113(4):1406-1416.
Environ Toxicol.2024, 39(5):2927-2936.
J Int Med Res.2021, 49(7):3000605211032849.
Korea Institute of Oriental Medicine2020, doi: 10.21203.
Molecules.2018, 23(12):E3103
Metabolites.2019, 9(11):E271
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Bioorg Med Chem. 2016 Dec 27. pii: S0968-0896(16)31162-2.
Anti-tuberculosis activity and structure-activity relationships of oxygenated tricyclic carbazole alkaloids and synthetic derivatives.[Pubmed:
28094223 ]
METHODS AND RESULTS:
A series of 49 oxygenated tricyclic carbazole derivatives has been tested for inhibition of the growth of Mycobacterium tuberculosis and a mammalian cell line (vero cells). From this series, twelve carbazoles showed a significant anti-TB activity.
CONCLUSIONS:
The four most active compounds were the naturally occurring carbazole alkaloids Clauszoline M (45), murrayaline C (41), carbalexin C (27), and the synthetic carbazole derivative 22 with MIC90 values ranging from 1.5 to 3.7μM. The active compounds were virtually nontoxic for the mammalian cell line in the concentration range up to 50μM.
