Chinensine B
Chinensine B and Chinensines A, C, D and Ε are antitumor diterpenoids.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Sci Rep.2019, 9:12132
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Metabolites.2020, 11(1):E11.
University of Guelph2021, 12.
J Agric Food Chem.2020, 68(51):15164-15175
Int J Mol Sci.2017, 18(5)
Molecules2022, 27(14),4462
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University of Crete, Faculty of Engineering and Technology: Department of Chemistry, 2008.
Total syntheses of the natural products Zerumin B, Chinensines A-E and Premnalane A in the context of biomimetic photochemical transformations mediated by molecular oxygen[Reference:
WebLink]
METHODS AND RESULTS:
In this dissertation the successful syntheses of natural products that exhibit interesting biological activities are described. In particular, the first total synthesis of the antitumor diterpenoids Chinensine B (3) and Chinensines A, C, D and Ε (2, 4-6) is disclosed herein. En route to the Chinensines, Coronarin E (1), as well as natural products 65, 79 and Villosin (92) were synthesized.
CONCLUSIONS:
Synthesis of the aforementioned natural products facilitated elucidation of their absolute stereochemistry. The regioselective synthesis of antitumor diterpenoids (+)-Zerumin B (7) and (+)-12-epi-Zerumin B (8)141 was also achieved.
