Coronarin D ethyl ether

Coronarin D ethyl ether
Product Name Coronarin D ethyl ether
CAS No.: 138965-89-6
Catalog No.: CFN99439
Molecular Formula: C22H34O3
Molecular Weight: 346.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: NF-KB
Source: The rhizomes of Hedychium coronarium
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Applied Biological Chemistry2022, 65(77).
  • Int J Mol Sci.2019, 20(9):E2244
  • Sci Rep.2018, 8:15059
  • New Journal of Chemistry2019, 43:12538-12547
  • Phytomedicine Plus2022, 2(1):100207.
  • The University of Manitoba2021, 35690.
  • Int J Mol Sci.2023, 24(18):13713.
  • Journal of Food and Drug Analysis2023, 31(3), 9.
  • Nutrients.2024, 16(20):3521.
  • Journal of Research in Pharmacy.2022, 26(6):p1752-1757.
  • Vitexilactone

    Catalog No: CFN97047
    CAS No: 61263-49-8
    Price: Inquiry(manager@chemfaces.com)
    12-Hydroxy-8(17),13-labdadien-16,15-olide

    Catalog No: CFN97538
    CAS No: 958885-86-4
    Price: Inquiry(manager@chemfaces.com)
    Villosin

    Catalog No: CFN99674
    CAS No: 160598-92-5
    Price: Inquiry(manager@chemfaces.com)
    Galanolactone

    Catalog No: CFN99258
    CAS No: 115753-79-2
    Price: Inquiry(manager@chemfaces.com)
    Isocoronarin D

    Catalog No: CFN99438
    CAS No: 138965-88-5
    Price: Inquiry(manager@chemfaces.com)
    Coronarin D

    Catalog No: CFN99302
    CAS No: 119188-37-3
    Price: Inquiry(manager@chemfaces.com)
    Coronarin D methyl ether

    Catalog No: CFN99667
    CAS No: 157528-81-9
    Price: Inquiry(manager@chemfaces.com)
    Coronarin D ethyl ether

    Catalog No: CFN99439
    CAS No: 138965-89-6
    Price: Inquiry(manager@chemfaces.com)
    15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one

    Catalog No: CFN89136
    CAS No: 1374328-47-8
    Price: Inquiry(manager@chemfaces.com)
    Hedycoronen A

    Catalog No: CFN89375
    CAS No: 1383441-73-3
    Price: Inquiry(manager@chemfaces.com)
    Bioorg Med Chem Lett. 2011 Dec 15;21(24):7460-5.
    Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells.[Pubmed: 22071304]
    The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine.
    METHODS AND RESULTS:
    From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance spectroscopy. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-α, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19±0.11 to 10.38±2.34 μM. The remains of compounds showed inactivity or due to cytotoxicity.
    CONCLUSIONS:
    These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium.
    Nat Prod Res. 2008;22(14):1249-56.
    Labdane diterpenes from the rhizomes of Hedychium coronarium.[Pubmed: 18932088]

    METHODS AND RESULTS:
    A new labdane diterpenoid, (E)-labda-8(17),12-dien-15,16-olide (1) together with eight known compounds, coronarin D (2), coronarin D methyl ether (3), Coronarin D ethyl ether (4), isocoronarin D (5), coronarin B (6), labda-8(17),11,13-trien-15,16-olide (7), (E)-labda-8(17),12-diene-15,16-dial (8) and 16-hydroxylabda-8(17),11,13-trien-15,16-olide (9), are isolated from the rhizomes of Hedychium coronarium. Compounds 2-4, 5 and 9 are isolated as mixtures of C-15, C-14 and C-16 epimers, respectively.
    CONCLUSIONS:
    Their structures are determined on the basis of their spectroscopic data. The epimeric mixtures of 2 and 3 have not been reported before. Some of them were evaluated for their cytotoxicity.
    Obovatol

    Catalog No: CFN95054
    CAS No: 83864-78-2
    Price: $318/5mg
    1-Phenyl-2-propanol

    Catalog No: CFN95129
    CAS No: 14898-87-4
    Price: $30/20mg
    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

    Catalog No: CFN95197
    CAS No: 1809980-25-3
    Price: $318/10mg
    Quercetin 7-O-(6''-O-malonyl)-beta-D-glucoside

    Catalog No: CFN95208
    CAS No: 98767-37-4
    Price: $388/10mg
    (+)-Lariciresinol 4'-O-beta-D-Glucopyranosyl-(1->3)-beta-D-glucopyranoside

    Catalog No: CFN95283
    CAS No: 639857-95-7
    Price: $463/5mg
    Fortunellin-6''-beta-D-glucopyranoside (Acacetin-7-O-[2''-O-rhamnosyl-6''-O-glucosyl]-glucoside)

    Catalog No: CFN95315
    CAS No: 1218774-64-1
    Price: $318/5mg
    Foliachinenoside C

    Catalog No: CFN95361
    CAS No: 1041180-87-3
    Price: $368/5mg
    New compound 13

    Catalog No: CFN95374
    CAS No: N/A
    Price: $318/5mg
    (R)-Mucronulatol

    Catalog No: CFN95492
    CAS No: 57128-11-7
    Price: $318/10mg
    Ganoderic acid Df

    Catalog No: CFN95514
    CAS No: 1352033-73-8
    Price: $318/5mg