Cedrin

Cedrin
Product Name Cedrin
CAS No.: 75513-81-4
Catalog No.: CFN97872
Molecular Formula: C16H14O8
Molecular Weight: 334.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: Bcl-2/Bax | Caspase | Beta Amyloid
Source: The herbs of Cedrus deodara
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • Biochem Pharmacol.2020, 178:114083
  • Academic J of Second Military Medical University2019, 40(1)
  • Phytomedicine.2018, 38:45-56
  • Nutrients.2019, 12(1):E40
  • Molecules.2019, 24(11):E2102
  • J Agric Food Chem.2018, 66(1):351-358
  • Oncotarget.2017, 8(64):108006-108019
  • Dihydromorin

    Catalog No: CFN99854
    CAS No: 18422-83-8
    Price: $403/5mg
    Dihydrotamarixetin

    Catalog No: CFN97194
    CAS No: 70411-27-7
    Price: Inquiry(manager@chemfaces.com)
    Blumeatin B

    Catalog No: CFN97274
    CAS No: 79995-67-8
    Price: Inquiry(manager@chemfaces.com)
    Dihydrorobinetin

    Catalog No: CFN98671
    CAS No: 4382-33-6
    Price: $338/20mg
    Ampelopsin

    Catalog No: CFN98326
    CAS No: 27200-12-0
    Price: $30/20mg
    Sepinol

    Catalog No: CFN97204
    CAS No: 72061-63-3
    Price: Inquiry(manager@chemfaces.com)
    Cedeodarin

    Catalog No: CFN97912
    CAS No: 31076-39-8
    Price: Inquiry(manager@chemfaces.com)
    Cedrin

    Catalog No: CFN97872
    CAS No: 75513-81-4
    Price: Inquiry(manager@chemfaces.com)
    (-)-Dihydroquercetin

    Catalog No: CFN92413
    CAS No: 111003-33-9
    Price: Inquiry(manager@chemfaces.com)
    Taxifolin

    Catalog No: CFN98734
    CAS No: 480-18-2
    Price: $30/20mg
    Nat Prod Res. 2017 Jun 29:1-4.
    Cedrin identified from Cedrus deodara (Roxb.) G. Don protects PC12 cells against neurotoxicity induced by Aβ1-42.[Pubmed: 28658984 ]
    Alzheimer's disease is a severe neurodegenerative disease affecting elder worldwide and closely related to the neurotoxicity induced by amyloid β.
    METHODS AND RESULTS:
    To find efficient therapeutics, we have investigated the protective effects of Cedrin from Cedrus deodara (Roxb.) G. Don on PC12 cells against the neurotoxicity induced by amyloid β1-42. The results have shown the viability of PC12 cells injured by amyloid β1-42 can be improved by Cedrin. Cedrin can reduce reacrive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content. Meanwhile, the loss of mitochondrial membrane potential and mitochondrial permeability transition pore opening in PC12 cells, and elevated Caspase-3 activity, downregulated Bcl-2 and upregulated Bax are meliorated.
    CONCLUSIONS:
    These results demonstrate the protective effect of Cedrin is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. This investigation gives evidences for the application of Cedrin in practice and further investigation in vivo.
    Poncirin

    Catalog No: CFN90448
    CAS No: 14941-08-3
    Price: $218/20mg
    7-Hydroxyaristolochic acid A

    Catalog No: CFN90517
    CAS No: 79185-75-4
    Price: $220/5mg
    Methylnissolin-3-O-glucoside

    Catalog No: CFN93199
    CAS No: 94367-42-7
    Price: $188/20mg
    Mirificin-4'-O-glucoside

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg
    5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)

    Catalog No: CFN95137
    CAS No: 105955-04-2
    Price: $268/20mg
    ent-16beta,17-dihydroxy-9(11)-kauren-19-oic acid

    Catalog No: CFN95172
    CAS No: 55483-24-4
    Price: $318/10mg
    Pterodonoic acid

    Catalog No: CFN95183
    CAS No: 62458-42-8
    Price: $413/5mg
    New compound 3

    Catalog No: CFN95184
    CAS No: N/A
    Price: $368/5mg
    Securoside A

    Catalog No: CFN95294
    CAS No: 107172-40-7
    Price: $318/5mg
    Fortunellin-6''-beta-D-glucopyranoside (Acacetin-7-O-[2''-O-rhamnosyl-6''-O-glucosyl]-glucoside)

    Catalog No: CFN95315
    CAS No: 1218774-64-1
    Price: $318/5mg