Cassipourine
Cassipourine and gerrardine show antibacterial activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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S Afr Med J. 1967 Feb 4;41(5):94-6.
Antibiotic activity of gerrardine and cassipourine alkaloids from plants of the family Rhizophoraceae.[Reference:
WebLink]
METHODS AND RESULTS:
Two alkaloids, gerrardine and Cassipourine, isolated from plants of the family Rhizophoraceae, were investigated for antibacterial activity in view of their novel structure. Gerrardine was found to have activity against a number of Enterobacteriaceae strains. Activity was dependent on inoculum size but not the age of the organisms. The effect appeared to be bactericidal. Cassipourine had simila...
The Alkaloids: Chemistry and Pharmacology, 1985,26: 53–87.
Chapter 2 Sulfur-Containing Alkaloids[Reference:
WebLink]
METHODS AND RESULTS:
A great variety of structures with different chromophores were recognized together with different numbers of sulfur atoms (one to four), which could be placed either in the side chain or in the ring. The increasing interest in this group of alkaloids is connected with new structures and chemical properties as well as with pharmacological activity. The sulfur-containing alkaloids may be classified in many ways. This chapter provides a guide for the classification, which denotes the number of sulfur atoms and their presence in the side chain or in the ring.
CONCLUSIONS:
Alkaloids with one sulfur atom in the side chain are described, which include erysothiovine and erysothiopine, 4-methylthiocanthin-6-one, zapotidine, planchonellin, japindine, and resedinine and related alkaloids. Alkaloids with one sulfur atom in the ring include chuangxinmycin, alkaloid TM-64, ferrithiocin, myxothiazol, and xylostosidine and its S-oxides. The chapter also describes alkaloids with more than one sulfur atom, such as brugine, gliotoxin, gliovirine, sporidesmins, sirodesmins, hyalodendrin, and Cassipourine and related alkaloids. sulfur-containing alkaloids of peptide structure are also discussed.
