Baicalein 7-O-beta-D-ethylglucuronide
Baicalein 7-O-beta-D-ethylglucuronide is a natural product from Scutellaria baicalensis Georgi.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Nat Prod Res. 2014;28(20):1772-6.
A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi.[Pubmed:
24995563 ]
METHODS AND RESULTS:
A new flavone glycoside, wogonin 7-O-β-D-ethylglucuronide (1), together with a new natural flavone glycoside baicalein 7-O-β-D-ethylglucuronide (Baicalein 7-O-beta-D-ethylglucuronide,2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-β-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses.
CONCLUSIONS:
Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 μM and 24.9 μM, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 μM and 3.0 μM.
Journal of Applied Pharmaceutical Science, 2013, 3(12):46-51.
Evaluation of wound healing activity of baicalein-7-O- β-Dglucuronide isolated from Leucas aspera[Reference:
WebLink]
Leucas aspera (Willd.) Linn. (Lamiaceae), commonly known as "Thumbai," is distributed throughout India.
This study includes the isolation and characterization of flavonoids present in Leucas aspera flowers were compared wound healing activity with standard soframycin ointment.
METHODS AND RESULTS:
The plant materials were extracted with 95% methanol, petroleum ether, ethyl acetate, and were subjected to column and TLC chromatographic separation analysis. The chemical constituents isolated from the flowers of L. aspera were characterized based on chemical tests and spectral analysis such as UV and NMR spectroscopy. The structure of the isolated compound was confirmed as baicalein-7-O- β-D-glucuronide (baicalin). It has been investigated for wound healing activity by applying on the albino rats. A slow rate of healing was observed earlier which turns to very rapid on the 12th day. The histopathological examination provided additional evidence for the experimental wound healing studies. Protease is a biochemical marker and pH measured to support the wound healing activity.
CONCLUSIONS:
We conclude that the baicalin isolated with the flowers of L. aspera has better wound healing activity.
