Aphagranin A

Aphagranin A
Product Name Aphagranin A
CAS No.: 1318173-53-3
Catalog No.: CFN96579
Molecular Formula: C33H54O6
Molecular Weight: 546.79 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The stem barks of Aphanamixis grandifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Metabolites.2023, 13(6):689.
  • Plant Physiol.2024, 194(4):2580-2599.
  • J Nat Prod.2021, 84(9):2544-2553.
  • J Separation Science & Technology2016, 51:1579-1588
  • Molecules.2017, 22(12)
  • Toxicol In Vitro.2022, 81:105346.
  • Sci Rep.2017, 7:40345
  • PLoS One.2017, 12(3):e0173585
  • Phytomedicine.2022, 96:153877.
  • Front Mol Neurosci.2023, 15:1083189.
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    METHODS AND RESULTS:
    Two novel tirucallane C27-triterpenoid epimers, aphagranins A (1) and B (2), featuring an unprecedented enolized cyclopentenone presented in the side-chain at C-17, were isolated from the stem barks of Aphanamixis grandifolia. Extensive spectroscopic analyses helped the establishment of the structures of the two isolates, whose absolute configurations were determined using density functional theory (DFT) calculations of optical rotation, and electronic circular dichroism (ECD).
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    Remarkable discrepancies in the inhibitory activities against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823) were found for the two epimers: with IC50 less than 10 μM, Aphagranin A exhibited much stronger antiproliferative activity than aphagranin B, showing no such activities with IC50 over 20 μM.
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    METHODS AND RESULTS:
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    CONCLUSIONS:
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