Kulinone

Kulinone
Product Name Kulinone
CAS No.: 21688-61-9
Catalog No.: CFN92977
Molecular Formula: C30H48O2
Molecular Weight: 440.70 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The seeds of Melia toosendan
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Kulinone has cytotoxic effects, with IC₅₀ values of 5.6-21.2 ug/mL, it inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Wageningen University & Research2018, January 2018
  • Medicina (Kaunas).2020, 56(12):685.
  • Process Biochemistry2019, 85:106-115
  • Pharmacol Rep.2019, 71(2):289-298
  • Biomed Pharmacother.2022, 145:112410.
  • Molecules.2021, 26(3):695.
  • Cell Death Differ.2021, 1-8.
  • Enzyme Microb Technol.2019, 122:64-73
  • Green Chemistry2021, ISSUE 2.
  • Oncotarget.2017, 8(53):90925-90947
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    METHODS AND RESULTS:
    Two new triterpenoids (1, 2) and two new steroids (3, 4) along with twelve related known compounds (5-16) were isolated from the bark of Melia azedarach. The new structures were elucidated by means of spectroscopic methods and molecular modeling studies and found to be 21,24-cycloeupha-7-ene-3 β,16 β,21 α,25-tetrol (1), 3 β-acetoxy-12 β-hydroxy-eupha-7,24-dien-21,16 β-olide (2), 29-hydroperoxy-stigmasta-7,24(28) E-dien-3 β-ol (3), and 24 ξ-hydroperoxy-24-vinyl-lathosterol (4). All isolated compounds were tested for their cytotoxic activity against three human cancer cell lines (A549, H460, HGC27) using the CellTiter Glo™ luminescent cell viability assay.
    CONCLUSIONS:
    Among them, compounds 2- 4, 24 ξ-hydroperoxy-24-vinyl-cholesterol (6), Kulinone (7), meliastatin 3 ( 8), 3-oxo-olean-12-en-28-oic acid (10), and (22 E,24 S)-5 α,8 α-epidioxy-24-methyl-cholesta-6,22-dien-3 β-ol (12) were found to have cytotoxic effects, with IC₅₀ values of 5.6-21.2 μg/mL.
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    CONCLUSIONS:
    Structures for each of the 11 euphane triterpenes were established by spectral techniques that included HRMS and 2D NMR.
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