Anabasamine
Reference standards.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Farmakol Toksikol. 1978 Jan-Feb;41(1):52-5.
Inhibiting effect of anabasine, anabasamine and lupinine alkaloids on ethanol action in mice.[Pubmed:
624390 ]
METHODS AND RESULTS:
Anabisis aphylla alcaloids anabasine, Anabasamine and lupinine (1/6 and 1/3) DL50, intraperitoneally) lowered the locomotion excitation called forth by aethanol (2 mg/g, by mouth) in mice. Lupinine shortened roughly by a foctor of 3 also the duration of aethanol anesthesia.
CONCLUSIONS:
The reduced excitation was attended by falling a blood aethanol concentration, while shortening of the anesthesia period was not, this suggesting different mechanisms in two disclosed antialcoholic effects of the alcaloids.
Tetrahedron Volume 39, Issue 1, 1983, Pages 41-47
Steroidal alkaloids (batrachotoxins and 4β-hydroxybatrachotoxins), “indole alkaloids” (calycanthine and chimonanthine) and a piperidinyldipyridin[Reference:
WebLink]
METHODS AND RESULTS:
Skin extracts from the Colombian poison-dan frog Phytlobates terribilis contain three major steroidal alkaloids; Batrachotoxin, homobatrachotoxin and batrachotoxinin A. Minor congeners of batrachotoxin and homobalrachotoxin containing a 4β-OH substituent are identified based on mass spectra and proton and carbon-13 NMR.
CONCLUSIONS:
Two “indole alkaloids” 1-calycanthine and d-chimonanthine, enantiomeric to the same compounds from plants, and norAnabasamine (5-(2-piperidyl)2,3'-dipyridine), a des-N-Me analog of the plant alkaloid Anabasamine, are present as minor constituents.
J Asian Nat Prod Res. 2008 Nov-Dec;10(11-12):1093-5.
Alkaloids from Anabasis aphylla L.[Pubmed:
19031252 ]
METHODS AND RESULTS:
A new pyridine alkaloid 1, together with three known alkaloids N-methylanabasine (2), Anabasamine (3), and isonicoteine (4), was isolated from the aerial part of Anabasis aphylla L. Their structures were elucidated by spectroscopic analysis.
