Lobelanidine
Lobelanidine is a chemical constituent from from Lobelia chinensis Lour, Lobelia chinensis Lour possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chin J Nat Med. 2014 Feb;12(2):103-7.
Lobelia chinensis: chemical constituents and anticancer activity perspective.[Pubmed:
24636059]
METHODS AND RESULTS:
Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as Lobelanidine, lobeline, and lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer).
CONCLUSIONS:
This paper focuses on the properties, chemical constituents, and anticancer activity of L. chinensis to clarify the connection among them, and identify the active anticancer compounds. This work serves as the foundation for further research and development of L. chinensis.
Bioorg Med Chem. 2009 Mar 1;17(5):1837-9.
Synthesis of (-)-lobeline via enzymatic desymmetrization of lobelanidine.[Pubmed:
19217305]
METHODS AND RESULTS:
The bioactive alkaloid (-)-lobeline was synthesized via the stereoselective acylation (desymmetrization) of meso-Lobelanidine by vinyl acetate in the presence of Candida antarctica lipase B.
