8-Hydroxy-9,10-diisobutyryloxythymol
8-Hydroxy-9,10-diisobutyryloxythymol shows cytotoxicity on six cancer cell lines (K562, HT-29, SGC-7901, DU145, MDA-MB-231, U251). 8-Hydroxy-9,10-diisobutyryloxythymol may have antibacterial activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Acta Botanica Yunnanica, 2009, 31(2):190-192.
New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae).[Reference:
WebLink]
METHODS AND RESULTS:
A new thymol derivative, 8-hydroxy-9,10-dioxyisopropylidenethymol (1), together with three known thymol derivatives 10-hydroxy-8, 9-dioxyisopropylidenethymol (2), 8-Hydroxy-9,10-diisobutyryloxythymol (3) and 8, 10-dihydroxy-9-isobutyryloxy-thymol (4), was isolated from 95% EtOH extract of the flowers of Inula helianthus-aquatica. Their structures were elucidated on the basis of detailed spectroscopic analysis.
CONCLUSIONS:
These compounds showed cytotoxicities on six cancer cell lines (K562, HT-29, SGC-7901, DU145, MDA-MB-231, U251), and compound 2 is the strongest one with IC50s of 4.20-33.12 μmol/L. This is the first time that the cytotoxic thymol derivatives were isolated from this titled plant.
Molecules. 2007 Jan 27;12(8):1606-13.
Antibacterial thymol derivatives isolated from Centipeda minima.[Pubmed:
17960076]
METHODS AND RESULTS:
Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-Hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature.
CONCLUSIONS:
The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
