5-O-Methylgenistein
5-O-Methylgenistein may show free radical scavenging activity, it also may have hepatoprotective property on the model of toxic hepatitis induced by carbon tetrachloride damage.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Eksp Klin Farmakol. 2014;77(2):26-30.
Hepatoprotective properties of isoflavonoids from roots of Maackia amurensis on experimental carbon tetrachloride-induced hepatic damage.[Pubmed:
24791337]
Hepatoprotective properties of ethanol extract from the roots of Maackia amurensis Ruper et Maxim have been studied on the model of toxic hepatitis induced by carbon tetrachloride damage.
METHODS AND RESULTS:
It is established that the extract contains daidzein, 7-O-gentobiosides of isoflavonoids genistein, formononetin, pseudobabtige-nin, and 5-O-Methylgenistein, and 3-O-gentobiosides of pterocarpans (6aR, 11aR)-maakiain and (6aR, 11aR)-medicarpin. The administration of extract facilitates the restoration of antioxidant protection enzymes activity and reduced glutathione level, decreases the formation of toxic peroxidation products, produces normalizing impact on liver phospholipid pattern, and improves the erythrocyte tolerance to hemolytic agents.
CONCLUSIONS:
The action of isoflavonoids from Maackia amurensis in restoration of metabolic pathways of the liver and removal of toxic stress was more effective as compared to that of the reference hepatoprotector legalon.
Phytochemistry Letters, 2009, 2(4):148-151.
Stilbene glucosides from the bulbs of Iris tingitana.[Reference:
WebLink]
METHODS AND RESULTS:
Two new dimeric stilbene glucosides, tingitanol A (1) and tingitanol B (2) together with trans-resveratrol 3-O-glucopyranoside (3) in addition to three known isoflavones, 5-O-Methylgenistein (4), 5-O-Methylgenistein 7-O-β-d-glucopyranoside (5) and betavulgarin (6) have been isolated for the first time from the fresh bulbs of Iris tingitana Boiss. & Reut.
CONCLUSIONS:
Their structures were established on the basis of the spectral data and direct comparison with values from previously identified analogues. Additionally, the isolated compounds (1–6) were evaluated for the free radical scavenging activity.
