5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone | CAS:98187-98-5

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Beziehung zwischen dem UV-Absorptionsmuster einiger Flavone und ihrer gegen L1210-Zellen cytotoxischen Aktivität[Reference: WebLink]

METHODS AND RESULTS:
The UV-pattern of several flavones, their cytotoxicities against L1210 cell and their Inhibiting effects on ATPase from the cell seem to be correlated. 5,2′-Dihydroxy-6,7,8,6′-tetramethoxyflavone (ED50=2.3 ug/ml) and 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED50=4.5 ug/ml), the most active flavones studied, have shown a narrow range of the absorbance ratio, Log εII/Log εI=1.073～1.109. They have inhibited the ATPase-activity to the greatest extent.
CONCLUSIONS:
These findings suggest that a certain angle between the flavone rings B and C plays an important role for the inhibition of the enzyme activity and thus the cytotoxicity.

Product Name	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone
CAS No.:	98187-98-5
Catalog No.:	CFN92215
Molecular Formula:	C₁₈H₁₆O₈
Molecular Weight:	360.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Targets:	ATPase
Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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