4-O-Methylgrifolic acid | CAS:118040-60-1

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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase II.[Reference: WebLink]

Carbonic anhydrase II (CAII) is an important enzyme complex with Zn2+,which is involved in many physiological and pathological processes, such as calcification, glaucoma and tumorigenicity.
METHODS AND RESULTS:
In order to search for novel inhibitors of CAII, inhibition assay of carbonic anhydrase II was performed, by which seven natural phenolic compounds, including four phenolics (grifolin, 4-O-Methylgrifolic acid, grifolic acid, and isovanillic acid) and three flavones (eriodictyol, quercetin and puerin A), showed in-hibitory activities against CAII with IC50s in the range of 6.37-71.73 umol/L. Grifolic acid is the most active one with IC50 of 6.37 umol/L.
CONCLUSIONS:
These seven phenolic compounds were proved to be novel natural carbonic anhydrase II inhibitors, which were obtained in flexible docking study with GOLD 3.0 soft-ware. Results indicated that the aliphatic chain and polar groups of hydroxyl and carboxyl are impor-tant to their inhibitory activities, providing a new insight into study on CA II potent inhibitors.

Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1176-9.

Cyathane diterpenoids and nitrogenous terphenyl derivative from the fruiting bodies of basidiomycete Phellodon niger.[Pubmed: 20823596]

METHODS AND RESULTS:
Two new cyathane-type diterpenoids, nigernin A and B (1, 2), one new nitrogenous terphenyl derivative, phellodonin (3), together with three known compounds, 2',3'-diacetoxy-3,4,5',6',4''-pentahydroxy-p-terphenyl, grifolin, and 4-O-Methylgrifolic acid, were isolated from the fruiting bodies of basidiomycete Phellodon niger. The structures of these new compounds were elucidated by spectroscopic methods and comparison with the data of known compounds in the literature.
CONCLUSIONS:
All these compounds were isolated from this fungus for the first time.

Product Name	4-O-Methylgrifolic acid
CAS No.:	118040-60-1
Catalog No.:	CFN96985
Molecular Formula:	C₂₄H₃₄O₄
Molecular Weight:	386.53 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Targets:	Carbonic anhydrase II
Source:	The fruiting bodies of basidiomycete Phellodon niger.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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