3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid
3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid exhibits potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 uM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Mol Biol Rep.2023, 50(5):4029-4038.
Antioxidants (Basel).2020, 9(11):1121.
Phytother Res.2023, 37(10):4587-4606.
Cell Death Discov.2023, 9(1):350.
Biomedicine & Pharmacotherapy2022, 153:113404.
Front Microbiol.2022, 12:833233.
Molecules.2019, 24(4):E709
Plants (Basel).2022, 11(21):2947.
Molecules.2023, 28(8):3376.
Nutr Res Pract.2023, 17(4):670-681.
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Planta Med. 2017 Jul 12.
Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus.[Pubmed:
28701018]
METHODS AND RESULTS:
Phytochemical investigation of the leaves and twigs of Lithocarpus litseifolius and Lithocarpus corneus resulted in the isolation of four new triterpenoids (1-4), three triterpenoids (5-7) isolated from a natural source for the first time, and six known compounds (8-13). In addition, four known triterpenoids (14-17) were isolated from L. corneus. Compound 1 is a 3,4-seco-lupane-type triterpenoid, and compounds 2-4 are lupane-type triterpenoids in different oxidation states. The structures of all isolated compounds were identified by spectroscopic methods, especially NMR and mass spectrometry data. The absolute configuration of 2 and 3 was confirmed by X-ray single crystallographic analysis. The anti-inflammatory activities of 1-17 and anti-HIV activities of 2-17 were evaluated.
CONCLUSIONS:
Among them, 3-epi-betulinic acid (8) showed a strong anti-HIV activity comparable to abacavir, a drug used for treating HIV/AIDS. 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid (3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid ,5) exhibited potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 μM.
