Ceanothic acid
Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Nat Prod. 1998 Nov;61(11):1343-7.
Preparation and cytotoxic effect of ceanothic acid derivatives.[Pubmed:
9834149 ]
METHODS AND RESULTS:
Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from Ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-Ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.
Journal of the Chinese Chemical Society.1993 Apr;40(2):213–216.
Microbial Transformation of Ceanothic Acid and Derivatives by Mycobacterium sp.[Reference:
WebLink]
METHODS AND RESULTS:
Ceanothic acid (1) is the major triterpene isolated from Parliurus ramosissitnus (Rhamnaceae) which possesses three methyl groups corresponding to the 4,4,14α-trimethyl groups in lanosterol (5). Microbial transformation of Ceanothic acid and its 3-dehydro-2,28-dimethyl ester derivative (3) with Mycobacterium sp. (NRRL B-3805) resulted in the methylation of the carboxylic functions and C-1 epimerization, respectively.
CONCLUSIONS:
Although this work indicates that Ceanothic acid is not a suitable substrate for 4,4,14α-tridemethylation, esterification of the carboxylic function and the C-1 epimerization reaction in Ceanothic acid and its derivative is the first observation with this microorganism.
