3,29-Dibenzoyl karounitriol
3,29-Dibenzoyl karounitriol is a natural product from Trichosanthes kirilowii Maxim.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Biomed Chromatogr . 2015 Aug;29(8):1229-34.
A rapid and sensitive LC-MS/MS method for quantification of 3,29-dibenzoyl rarounitriol in rat plasma: application to a pharmacokinetic study[Pubmed:
25611485]
Abstract
A rapid, sensitive and high-throughput liquid chromatography-tandem mass spectrometry was established and validated to assay the concentrations of 3,29-dibenzoyl rarounitriol in rat plasma. Plasma samples were processed by liquid-liquid extraction with ethyl acetate and separated on a Hypersil Gold C18 column (50 × 4.6 mm, 3 μm) at an isocratic flow rate of 0.5 mL/min using methanol-10 mm ammonium acetate-formic acid (90:10:0.1, v/v/v) as mobile phase. The total run time was 5 min for each sample. MS/MS detection was accomplished in selected reaction monitoring mode with positive electrospray ionization. The calibration curve was linear over the concentration range of 0.125-50 ng/mL with lower limit of quantification of 0.125 ng/mL. The intra- and inter-day precisions were <10.1% in terms of coefficient of variation, and the accuracy was within ±11.7% in terms of relative error. The developed method was successfully applied to a pharmacokinetic study of 3,29-dibenzoyl rarounitriol following intragastric administration of 3.65 mg/kg to Wistar rats.
Keywords: 3,29-dibenzoyl rarounitriol; Trichosanthes kirilowii; multiflorane triterpene esters; pharmacokinetics; rat plasma.
《Chinese Journal of Hospital Pharmacy》 2014-20
Quality control of GualouXiebai drop pills[Reference:
WebLink]
To establish a TLC identification method of GualouXiebai drop pills,and to develop a determination method of 3,29-Dibenzoyl karounitriol in GualouXiebai drop pills.
METHODS AND RESULTS:
The GualouXiebai drop pills were identified by TLC.The determination of 3,29-Dibenzoyl karounitriol was performed by HPLC-DAD. The results showed that GualouXiebai drop pills appeared corresponding spots with reference medicinal materials or control sample;3,29-Dibenzoyl karounitriol showed a good linear relationship at a range of 2.7 ~ 0.028 125 μg,the linear equation was Y = 545 399.834 2X + 6 081.705 9,r = 0.999 8,and the average recovery was 101.0%.RSD was 4.93%,the average content of 3,29-Dibenzoyl karounitriol in five batches of GualouXiebai drop pills was 0.053%.
CONCLUSIONS:
The method was simple,accurate,reproducible and specific,and suitable for the quality control of the GualouXiebai drop pills.
