Glutinone

Glutinone
Product Name Glutinone
CAS No.: 508-09-8
Catalog No.: CFN98802
Molecular Formula: C30H48O
Molecular Weight: 424.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: COX | LOX | PGE
Source: The herbs of Eragrostis ferruginea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Biol. Pharm. Bul., 2002, 25(1):1-4.
    Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity.[Pubmed: 11824534]

    METHODS AND RESULTS:
    Four sesquiterpenes isolated from Jasonia glutinosa D.C. (Asteraceae), namely lucinone, Glutinone, 5-epi-kutdtriol and kutdtriol, have been evaluated for their in vitro anti-inflammatory activity in cellular systems generating cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) metabolites. None of the compounds assayed had a significant effect on leukotriene C4 (LTC4)-release from calcium ionophore-stimulated mouse peritoneal cells. However, the release of prostaglandin E2 (PGE2) by mouse peritoneal cells stimulated with calcium ionophore was inhibited by these compounds, although with less potency than the reference drug indomethacin (IC50=0.24 microM). The IC50 values of the active compounds were: lucinone 42.69 microM, Glutinone 3.61 microM, 5-epi-kutdtriol 1.28 microM and kutdtriol 39 microM.
    CONCLUSIONS:
    Of the tested compounds, only Glutinone (IC50=24 microM) showed a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets, although with less potency than the reference drug ibuprofen (IC50=1.27 microM).
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    A facile and efficient asymmetric synthesis of Glutinone 1 and its C(7) and C(11) epimers 1b–d is presented, using the Sharpless asymmetric dihydroxylation reaction as the key step.
    CONCLUSIONS:
    By comparing the spectral data of the natural product with that of the synthetic samples, we could confirm the absolute configuration of Glutinone 1.
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