Taxcultine
Taxcultine can actively promote tubulin assembly.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Nat Prod. 1994 Jan;57(1):116-22.
New bioactive taxoids from cell cultures of Taxus baccata.[Pubmed:
7908950]
METHODS AND RESULTS:
Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named Taxcultine [4], contained an n-propyl group on the side-chain.
CONCLUSIONS:
All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.
Phytochemistry. 1996 Feb;41(3):803-5.
Isolation and semi-synthesis of a bioactive taxane from Taxus canadensis.[Pubmed:
8835457]
A minor bioactive taxane, isolated from the needles of Taxus canadensis and semi-synthesized, was shown to be Taxcultine.
