1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one shows growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes, with the IC(50) value in the range of 1-3 microg/mL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Adv Healthc Mater.2024, 13(13):e2303276.
Evid Based Complement Alternat Med.2018, 2018:1073509
Int. J. of Food Properties2017, S108-S118
Front Pharmacol.2021, 12:765521.
J Plant Biochem.Biotech.2024, 33:353-366.
Journal of Food Hygiene and Safety2019, 34(5):413-420
Universidade Estadual Paulista2017, 42785
Molecules.2019, 24(10):E1930
Nutrients.2023, 15(24):5020.
Food Chem.2022, 373(Pt B):131364.
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J Nat Prod. 2003 Mar;66(3):364-7.
Trypanocidal diarylheptanoids from Aframomum letestuianum.[Pubmed:
12662093 ]
METHODS AND RESULTS:
Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4'-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4'-dihydroxyflavanone, 7-methoxy-3,5,4'-trihydroxyflavone, and 3,3',4',5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes.
CONCLUSIONS:
IC(50) values in the range of 1-3 microg/mL were found for compounds 3 and 5.
