1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene
Product Name 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene
CAS No.: 63644-68-8
Catalog No.: CFN96093
Molecular Formula: C19H20O4
Molecular Weight: 312.4 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: PARP
Source: The rhizomes of Curcuma longa L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has cytotoxic activities and tumour-selectivities, it also has hypoglycemic activity.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Int J Mol Sci.2021, 22(16):8604.
  • Phytomedicine.2015, 22(11):1027-36
  • Free Radic Biol Med.2016, 97:307-319
  • J Pharmacopuncture.2023, 26(4):357-365.
  • Molecules.2022, 27(19):6681.
  • Nutr Res Pract.2020, 14(5):478-489.
  • J Clin Med.2022, 11(13):3662.
  • Sains Malaysiana2024, 53(4):795-805
  • Molecules.2023, 28(13):4972.
  • Biol Pharm Bull.2017, 40(6):797-806
  • 1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one

    Catalog No: CFN96790
    CAS No: 332371-82-1
    Price: $318/5mg
    1,7-Bis(4-hydroxyphenyl)hept-6-en-3-one

    Catalog No: CFN96302
    CAS No: 1251830-57-5
    Price: Inquiry(manager@chemfaces.com)
    Rubranol

    Catalog No: CFN98060
    CAS No: 211126-61-3
    Price: Inquiry(manager@chemfaces.com)
    Hirsutenone

    Catalog No: CFN98646
    CAS No: 41137-87-5
    Price: Inquiry(manager@chemfaces.com)
    Hannokinol

    Catalog No: CFN96248
    CAS No: 79120-40-4
    Price: $318/10mg
    3,5-Dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane

    Catalog No: CFN96858
    CAS No: 408324-00-5
    Price: $318/5mg
    5-Hydroxy-1,7-bis(4-hydroxyphenyl)heptan-3-yl acetate

    Catalog No: CFN96291
    CAS No: 1269839-24-8
    Price: $318/10mg
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Platyphyllonol

    Catalog No: CFN98644
    CAS No: 41137-85-3
    Price: Inquiry(manager@chemfaces.com)
    1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one

    Catalog No: CFN96210
    CAS No: 207792-17-4
    Price: Inquiry(manager@chemfaces.com)
    J. Enzym. Inhib. Med.Chem., 2015(3):1-6.
    Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.[Pubmed: 25068729 ]
    Aminomethyl derivatives of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene-3-one, designed as new cytotoxins, were synthesized and evaluated in terms of their cytotoxic activities.
    METHODS AND RESULTS:
    The compounds have low CC50 values in the low micromolar range against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells. In general, the average CC50 values of these compounds were higher towards HGF, HPC and HPLF non-malignant cells, which reveals the tumour-selectivity of these aminomethyl derivatives, Mannich bases.
    CONCLUSIONS:
    Using specific concentrations of compounds 4 and 6 caused cleavage of PARP1 in HSC-2 cells but not HGF cells, which may be a contributing factor to cytotoxicities and the tumour-selectivities.
    Lucidenic acid D2

    Catalog No: CFN95020
    CAS No: 98665-16-8
    Price: $268/5mg
    Parvisoflavanone

    Catalog No: CFN95077
    CAS No: 49776-79-6
    Price: $413/5mg
    3-O-[5'''-O-feruloyl-beta-D-apiofuranosyl(1'''->2'')-beta-D-glucopyranosyl] rhamnocitrin

    Catalog No: CFN95154
    CAS No: 148210-00-8
    Price: $413/5mg
    New compound 4

    Catalog No: CFN95185
    CAS No: N/A
    Price: $368/5mg
    Dichotomine B

    Catalog No: CFN95193
    CAS No: 755036-41-0
    Price: $318/5mg
    Isophysalin G

    Catalog No: CFN95328
    CAS No: 152221-21-1
    Price: $368/5mg
    2',4'-Dihydroxychalcone

    Catalog No: CFN95493
    CAS No: 1776-30-3
    Price: $318/20mg
    12beta-Acetoxy-7beta-hydroxy-3,11,15,23-tetraoxo-5alpha-lanosta-8,20-dien-26-oic acid

    Catalog No: CFN95515
    CAS No: 1245946-62-6
    Price: $318/5mg
    5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on

    Catalog No: CFN95522
    CAS No: 114579-31-6
    Price: $318/5mg
    New compound 19

    Catalog No: CFN95538
    CAS No: N/A
    Price: $413/5mg