1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene
Product Name 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene
CAS No.: 63644-68-8
Catalog No.: CFN96093
Molecular Formula: C19H20O4
Molecular Weight: 312.4 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: PARP
Source: The rhizomes of Curcuma longa L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has cytotoxic activities and tumour-selectivities, it also has hypoglycemic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    J. Enzym. Inhib. Med.Chem., 2015(3):1-6.
    Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.[Pubmed: 25068729 ]
    Aminomethyl derivatives of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene-3-one, designed as new cytotoxins, were synthesized and evaluated in terms of their cytotoxic activities.
    METHODS AND RESULTS:
    The compounds have low CC50 values in the low micromolar range against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells. In general, the average CC50 values of these compounds were higher towards HGF, HPC and HPLF non-malignant cells, which reveals the tumour-selectivity of these aminomethyl derivatives, Mannich bases.
    CONCLUSIONS:
    Using specific concentrations of compounds 4 and 6 caused cleavage of PARP1 in HSC-2 cells but not HGF cells, which may be a contributing factor to cytotoxicities and the tumour-selectivities.
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