Toxicity

alpha-Solanine
Catalog No: CFN90560

Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut. Alpha-Solanine has proliferation-inhibiting and apoptosis-promoting effect on multiple cancer cells, such as clone, liver, melanoma cancer cells.

3-O-(2'E ,4'Z-decadienoyl)-20-deoxyingenol
Catalog No: CFN92862

3-O-(2'E ,4'Z-decadienoyl)-20-deoxyingenol, one toxic terpenoid from raw Gansui. It has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships.

Kansuinine A
Catalog No: CFN92863

Kansuinine A possesses analgesic props, it also shows NGF inducing activity.

3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol
Catalog No: CFN92864

3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol, one toxic terpenoid from raw Gansui. It has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships . It shows antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces the cytotoxicity of intestinal epithelial cells of rats (IEC-6 cells) depends on induction of cell apoptosis via mitochondrial pathway and cell cycle arrest.3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol, kansuinine B and kansuinine A can markedly promote SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL, hence the they are believed to be important proinflammatory components of the roots of E. kansui.

Kansuinine B
Catalog No: CFN92866

Kansuinine B shows cytotoxic ,and analgesic activities, treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects.