Toxicity

Littorine
Catalog No: CFN00200

The kinetics of Littorine biosynthesis were in agreement with the role of this compound as a direct precursor of hyoscyamine biosynthesis.

2,4-Dihydroxyphenylacetic acid
Catalog No: CFN97051

2,4-Dihydroxyphenylacetic acid is a functional moiety in the toxin molecule and the biological action of spider toxin is explained by direct interaction with an Fe-S center which is known to play an important role for the glutamate binding.

Spathulenol
Catalog No: CFN97150

Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway; it presents moderate or low cytotoxicity with IC50 higher than 6uM, it is a good candidate to be used in combination chemotherapy of MDR cancer.

N-Acetylnorloline
Catalog No: CFN00293

High levels of N-acetyl norloline and peramine may be of particular importance for developing 'friendly' endophyte-enhanced turf and pasture grasses that resist challenging lepidopteran pests. N-acetyl norloline, which is produced by the Max P endophyte, may be responsible for a new form of toxicity called equine fescue oedema in horses.

Anacrotine
Catalog No: CFN00345

Anacrotine produces much more severe lung damage than most other pyrrolizidine alkaloids.