Toxicity

Isoline
Catalog No: CFN00351

Isoline can induce different oxidative injury in various important mouse organs, and of which liver is the most sensitive organ. Isoline decreases the cellular GSH and the ratio of GSH and oxidizes glutathione in a time- and concentration-dependent manner in L-02 cells. l-Buthionine-(S, R)-sulfoximine (BSO) and mercaptosuccinic acid (MA), inhibitors of GCL and GPx, both augmented Isoline-induced cytotoxicity in cultured mice hepatocytes.

Jacobine
Catalog No: CFN00375

Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.

Jacoline
Catalog No: CFN00376

Jacoline, jaconine, jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.

Jaconine
Catalog No: CFN00377

Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.

Otosenine
Catalog No: CFN00395

D-Otocenine elicites low toxicity, it shows spasmolytic properties .