Toxicity

3-O-(2'E,4'Z-Decadienoyl)ingenol
Catalog No: CFN92867

Kansuiphorin C and 3-O-(2′E,4′Z-decadienoyl)-ingenol exhibit significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8 and 89.5±5.5 uM. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball.

3-O-(2'E,4'E-Decadienoyl)ingenol
Catalog No: CFN92868

3-O-(2'E,4'E-Decadienoyl)ingenol , one toxic terpenoid from raw Gansui.3-O-(2′E,4′E-decadienoyl)-ingenol and 3-O-(2′E,4′Z-decadienoyl)-20-O-acetyl-ingenol show cytotoxicity on Namalwa cells with IC 50 values of 7.6 and 5.2 umol·L-1, respectively.

Enniatin B1
Catalog No: CFN97986

Enniatin B1 has antifungal effects. It induces apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Enniatin B1 also has intestinal toxicity.

7Beta-Hydroxycholesterol
Catalog No: CFN90610

7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. 7beta-Hydroxycholesterol and 7-ketocholesterol have dual cytotoxic effects on the cells of the vascular wall by their ability to induce apoptosis in endothelial and smooth muscle cells and necrosis in fibroblasts. 7beta-Hydroxycholesterol can inhibit the proliferation of NCI-H460 cells through apoptosis via caspase activation. It can reinforce the susceptibility of K562 adriamycin-resistant cells to this drug, it also can enhance radiosensitivity in RDM4 cells.

3-Deoxyaconitine
Catalog No: CFN90660

3-Deoxyaconitine has toxicity.