Toxicity

Kaempferol-3-beta-O-glucuronide
Catalog No: CFN90359

Kaempferol-3-beta-O-glucuronide has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal β-glucuronidase from various human cells.

Annonacin
Catalog No: CFN97856

Annonacin is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons; can cause significant cell death in various cancer cell lines. Annonacin induces growth arrest and apoptosis in ERα-related pathways in MCF-7 cells, attenuates MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases.

Eurycomanone
Catalog No: CFN92008

Eurycomanone has anti-cancer activity, it is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.

Canthin-6-one N-oxide
Catalog No: CFN92010

Canthin-6-one N-oxide has broad spectrum antifungal, leishmanicidal and trypanocidal activities.

9-Methoxycanthin-6-one
Catalog No: CFN92011

9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.