Cytotoxic

Momordin II
Catalog No: CFN92562

Highly purified Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity.

Phillygenin
Catalog No: CFN90511

Phillyrin, (+)-Phillygenin, and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(50) values.

Acetylshikonin
Catalog No: CFN90523

Acetylshikonin has anti-cancer and anti-inflammatory activity, it is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors. Certain shikonin derivatives(such as Acetylshikonin) act as modulators of the Nur77-mediated apoptotic pathway.

Baldrinal
Catalog No: CFN90525

Baldrinal, valtrate, and acevaltrate are the quality control compounds of Valeriana jatamansi Jones. Baldrinal shows selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines.

Corytuberine
Catalog No: CFN90528

Corytuberine was inhibited only by naloxone and that of bulbocapnine preferentially by yohimbine.