Cytotoxic

Licoflavone C
Catalog No: CFN92289

Licoflavone C has cytotoxic, and antioxidative effects, it has protective effect toward the chromosome damage induced by DAU or MMC in cultured human peripheral lymphocytes. Licoflavone C exhibits a dose-dependent antagonistic activity at concentrations up to 10−4 M, but stimulates β-galactosidase expression at higher concentrations resulting in a U-shaped-like dose-response curve.

Shikokianin
Catalog No: CFN92311

Shikokianin shows inhibitory effects on DU145 cells with IC(50) values 4.24 microM, and LoVo cells with IC(50) values 17.55 microM.

Dicentrine
Catalog No: CFN92331

Dicentrine, a selective α(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain. Dicentrine induces DNA lesions to arrest cell cycle. Callus and cell suspension cultures of S. venosa can produce high levels of Dicentrine as an alternative source of plant materials.

5-Methoxycanthin-6-one
Catalog No: CFN92362

5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC₅₀ values ranging from 13.5-15.4 uM versus doxorubicine with IC₅₀ = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosis response upon activation with serum-opsonized zymosan in the range of IC₅₀ = 0.9-2.0 uM versus ibuprofen with IC₅₀ = 12.1 uM.

Trametenolic acid
Catalog No: CFN92366

Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9 μM, K IS of 0.5 μM, and an IC50 of 7.25 μM.Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content.