Cytotoxic

Coronaridine
Catalog No: CFN92859

Coronaridine is an antitumor agent. Coronaridine congeners inhibit hα3β4 AChRs by blocking the ion channel's lumen and probably by additional negative allosteric mechanisms by interacting with a series of non-luminal sites.

Kansuiphorin C
Catalog No: CFN92861

Kansuiphorin C shows cytotoxic activity.

3-O-(2'E ,4'Z-decadienoyl)-20-deoxyingenol
Catalog No: CFN92862

3-O-(2'E ,4'Z-decadienoyl)-20-deoxyingenol, one toxic terpenoid from raw Gansui. It has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships.

3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol
Catalog No: CFN92864

3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol, one toxic terpenoid from raw Gansui. It has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships . It shows antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces the cytotoxicity of intestinal epithelial cells of rats (IEC-6 cells) depends on induction of cell apoptosis via mitochondrial pathway and cell cycle arrest.3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol, kansuinine B and kansuinine A can markedly promote SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL, hence the they are believed to be important proinflammatory components of the roots of E. kansui.

3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol
Catalog No: CFN92865

3-O-(2′E,4′E-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships.