Anti-proliferation

Platycodin D2
Catalog No: CFN93260

Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalacin D2 has anti-cancer activity, it exhibits significant inhibition on the proliferation of five kinds of cultured human tumor cell lines.

Beta-Elemonic acid
Catalog No: CFN90991

Beta-Elemonic acid exhibits anti-inflammatory, and anti-cancer effects, it inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.

Fucoxanthin
Catalog No: CFN90852

Fucoxanthin shows anti-obesity, antioxidant, anti-inflammatory, chemopreventive and/or chemotherapeutic effects. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. Fucoxanthin suppresses the inflammation of endotoxin-induced uveitis by blocking the iNOS and COX-2 protein expression and its anti-inflammatory effect on eye is comparable with the effect of predinisolone used in similar doses.

2,5-Dihydroxyacetophenone
Catalog No: CFN93182

2,5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity, it possesses anti-inflammatoryanti-anxiety, and neuroprotective qualities. 2,5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells.

Zingiberen newsaponin
Catalog No: CFN90832

Zingiberensis newsaponin I exhibits induction effect on platelet aggregation. Zingiberensis saponin can inhibit the proliferation of a panel of established human and murine cancer cell lines in vitro, its proliferation inhibitory effect is associated with its apoptosis-inducing effect by activation of caspase-3 and caspase-9 and specific proteolytic cleavage of poly (ADP-ribose) polymerase, thus, zingiberensis saponin is an effective natural agent for cancer therapy.