Zingiberen newsaponin
Zingiberensis newsaponin I exhibits induction effect on platelet aggregation. Zingiberensis saponin can inhibit the proliferation of a panel of established human and murine cancer cell lines in vitro, its proliferation inhibitory effect is associated with its apoptosis-inducing effect by activation of caspase-3 and caspase-9 and specific proteolytic cleavage of poly (ADP-ribose) polymerase, thus, zingiberensis saponin is an effective natural agent for cancer therapy.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Chin Med.2022, 17(1):66.
Phys Chem Chem Phys.2018, 20(23):15986-15994
Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
Food Chem.2020, 332:127412
Curr Top Med Chem.2020, 20(21):1898-1909.
Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
Metabolites2023, 13(1), 3.
Int J Nanomedicine.2024, 19:1683-1697.
Molecules.2021, 26(13):4081.
Separations2023, 10(2), 131.
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Zhongguo Zhong Yao Za Zhi.2014,39(19):3782-7.
Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities[Pubmed:
25612440]
METHODS AND RESULTS:
Using the absorbent resin, silica gel and ODS column chromatography as well as semi-preparative HPLC, ten compounds were isolated from 70% ethanol extract of tubers of Dioscorea zingiberensis C. H. Wright, and their structures were elucidated as trigoneoside XIIIa (1), parvifloside (2), trigoneoside IVa (3), deltoside (4), protobioside (5), lilioglycoside k (6), zingiberensis newsaponin I (7), deltonin (8), prosapogenin A of dioscin (9), and trillin (10) on the basis of NMR and MS spectral data analysis. Among these compounds, 1, 3, 5 and 6 were isolated from this plant for the first time.
CONCLUSIONS:
In the screening test on platelet aggregation, compounds 7 and 8 exhibited induction effect on platelet aggregation, while compound 9 exhibited significant inhibitory effect on platelet aggregation in vitro.
