Beta-Elemonic acid

Beta-Elemonic acid
Product Name Beta-Elemonic acid
CAS No.: 28282-25-9
Catalog No.: CFN90991
Molecular Formula: C30H46O3
Molecular Weight: 454.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: MAPK | ROS | COX | Bcl-2/Bax
Source: The sclerotium of Poria cocos (Schw.) Wolf
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Beta-Elemonic acid exhibits anti-inflammatory, and anti-cancer effects, it inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Nat Prod.2019, 82(4):1002-1008
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • J Agric Food Chem.2015, 63(44):9869-78
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Journal of Functional Foods2017, 30:30-38
  • J Ethnopharmacol.2016, 192:370-381
  • Med Sci Monit.2019, 25:9499-9508
  • Mol Cells.2018, 41(8):771-780
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Virulence.2018, 9(1):588-603
  • Beta-Elemonic acid

    Catalog No: CFN90991
    CAS No: 28282-25-9
    Price: Inquiry(manager@chemfaces.com)
    16 alpha-Hydroxytrametenolic acid

    Catalog No: CFN90803
    CAS No: 176390-68-4
    Price: $750/10mg
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid

    Catalog No: CFN90804
    CAS No: 168293-13-8
    Price: $418/10mg
    Dehydrotrametenolic acid

    Catalog No: CFN90577
    CAS No: 29220-16-4
    Price: $268/20mg
    16alpha-Hydroxydehydrotrametenolic acid

    Catalog No: CFN90790
    CAS No: 176390-66-2
    Price: $488/10mg
    3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

    Catalog No: CFN90791
    CAS No: 168293-14-9
    Price: $418/10mg
    Poricoic acid B

    Catalog No: CFN95050
    CAS No: 137551-39-4
    Price: $368/10mg
    Poricoic acid G

    Catalog No: CFN95056
    CAS No: 415724-84-4
    Price: $318/5mg
    Euphol

    Catalog No: CFN89516
    CAS No: 514-47-6
    Price: $288/10mg
    Lanosterol

    Catalog No: CFN92368
    CAS No: 79-63-0
    Price: $388/5mg
    Oncol Rep. 2016 Jan;35(1):227-34.
    β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion.[Pubmed: 26530631 ]
    Beta-Elemonic acid, a known triterpene, exhibits anti-inflammatory effects, yet research on the pharmacological effects of Beta-Elemonic acid is rare.
    METHODS AND RESULTS:
    We investigated the anticancer effects and the related molecular mechanisms of Beta-Elemonic acid on human non-small cell lung cancer (NSCLC) A549 cells. The effects of Beta-Elemonic acid on the growth of A549 cells were studied using a 3-(4,5)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected using Annexin V staining. The effect of Beta-Elemonic acid on the cell cycle of A549 cells was assessed using the propidium iodide method. The change in reactive oxygen species (ROS) was detected using a dichlorodihydrofluorescein diacetate (DCFH-DA) assay with microscopic examination. The expression levels of Bcl-2 family proteins, mitogen-activated protein kinase (MAPK) family proteins and cyclooxygenase 2 (COX-2) were detected using western blot analysis. Our data revealed that β-elemonic acid strongly induced human A549 lung cancer cell death in a dose- and time-dependent manner as determined by the MTT assay. Beta-Elemonic acid-induced cell death was considered to be apoptotic when the phosphatidylserine exposure was observed using Annexin V staining. The death of human A549 lung cancer cells was caused by apoptosis induced by activation of ROS activity, increase in the sub-G1 proportion, downregulation of Bcl-2 expression, upregulation of Bax expression and inhibition of the MAPK signaling pathways.
    CONCLUSIONS:
    These results clearly demonstrated that Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis. Moreover, the anticancer effects of Beta-Elemonic acid were related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells.
    J Nat Prod. 2005 Feb;68(2):189-93.
    Bioactive constituents from Boswellia papyrifera.[Pubmed: 15730241 ]

    METHODS AND RESULTS:
    Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), Beta-Elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10).
    CONCLUSIONS:
    The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.
    Prunasin

    Catalog No: CFN97566
    CAS No: 99-18-3
    Price: $223/5mg
    Vicenin -2

    Catalog No: CFN92031
    CAS No: 23666-13-9
    Price: $188/10mg
    Irigenin

    Catalog No: CFN93276
    CAS No: 548-76-5
    Price: $238/20mg
    Methylnissolin

    Catalog No: CFN90838
    CAS No: 733-40-4
    Price: $388/10mg
    Hamaudol

    Catalog No: CFN95115
    CAS No: 735-46-6
    Price: $318/5mg
    1-Phenyl-2-propanol

    Catalog No: CFN95129
    CAS No: 14898-87-4
    Price: $50/20mg
    Puerol B

    Catalog No: CFN95155
    CAS No: 112343-17-6
    Price: $398/5mg
    Cichoriin

    Catalog No: CFN95196
    CAS No: 531-58-8
    Price: $100/20mg
    Biatractylolide

    Catalog No: CFN95205
    CAS No: 182426-37-5
    Price: $268/10mg
    Isovalerylshikonin

    Catalog No: CFN95222
    CAS No: 52387-14-1
    Price: $318/10mg