Anti-proliferation

Allomatrine
Catalog No: CFN90222

Allomatrine can inhibit proliferation and invasion in vitro of human lung cancer A549 cell line by inducing ROS production,promoting apoptosis, arresting cell cycle, inhibiting ubiquitin proteasome and regulating tumor related gene expression. (+)-Allomatrine and (+)-matrine when given i.c.v. may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord, and this phenomenon in turn produces the antinociception in mice.

Uncinatone
Catalog No: CFN97587

Uncinatone exhibits moderate cytotoxicity, inhibits cell proliferation, and induces cell-cycle G(2)/M phase arrest, it demonstrates cytotoxic activities against the HL-60 tumour cell line (IC50 ＜ 20 uM). Uncinatone shows inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 87 uM. Uncinatone also exhibits inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 12.50 uM.

Casegravol
Catalog No: CFN97693

Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.

Sclareol
Catalog No: CFN90249

Sclareol possesses anti-cancer, anti-osteoarthritic, immune-regulation and anti-inflammatory activities, it inhibits the MMPs, iNOS and COX-2 expression on mRNA and protein levels, while increases the TIMP-1 expression, and over-production of NO and PGE2 is also suppressed by Sclareol ameliorated cartilage degradation. Sclareol induces plant resistance to root-knot nematode partially through ethylene-dependent enhancement of lignin accumulation.

Ganoderenic acid H
Catalog No: CFN90302

Ganoderenic acid H is one compound of triterpenoids isolated from Ganoderma lucidum, triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic activities.