Anti-proliferation

Chebulanin
Catalog No: CFN92294

Chebulanin is a topoisomerase I inhibitor, it inhibits the calcineurin pathway in C. neoformans. Chebulanin exhibits potent antifungal activity against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 μg/ml. Chebulanin shows strong radical scavenging activity, good potency to chelate Fe2⁺ and good inhibition ability of lipid peroxidation. Chebulanin is a strong therapeutic alternative for the treatment of rheumatism arthritis, it suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice.Chebulanin has anti-cancer acrtivity, it has apparent capacities of inhibiting the survival of MCF-7 human cancer cell line.

Chebulagic acid
Catalog No: CFN92295

Chebulagic acid is a potent DNA topoisomerase inhibitor, and is also COX-2 and 5-LOX dual inhibitor. Chebulagic acid may be of value as broad-spectrum antivirals for limiting emerging/ recurring viruses known to engage host cell glycosaminoglycans for entry. Chebulagic acid can be used to control blood glucose and manage type 2 diabetes, although clinical trials are needed.

Didymin
Catalog No: CFN92363

Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture, it induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Didymin possesses antioxidant, anti-inflammation and anti-cancer properties.

4-O-Feruloylquinic acid
Catalog No: CFN92392

4-O-Feruloylquinic acid can be useful for the prevention of cardiovascular and other chronic diseases.

Alisol A
Catalog No: CFN92542

Alisol A may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).