Hot Products

Nevadensin
Catalog No: CFN96492

Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL.

N-Feruloyloctopamine
Catalog No: CFN97707

Niazirin
Catalog No: CFN96998

The Moringa oleifera extract(including niaziridin and Niazirin) can successfully attenuate the development of pulmonary hypertension via direct vasodilatation and a potential increase in antioxidant activity.

Nicotiflorin
Catalog No: CFN99830

Nicotiflorin shows potent antiglycation activity and neuroprotection effects, it has protective effects on cerebral ischemic damage, reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.

Nicotinamide
Catalog No: CFN99926

Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1, it has insulinotropic action, it can induce differentiation and maturation of human fetal pancreatic islet cells. Nicotinamide may represent a safe treatment for Alzheimer's disease and other tauopathies, and that phosphorylation of tau at Thr231 may regulate tau stability.

Nicotinic acid
Catalog No: CFN91739

Nicotinic acid is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Nicotinic acid plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Nicotinic acid is also used in the study of cardiovascular diseases. IC50 & Target: Microbial Metabolite; Human Endogenous Metabolite

Niga-ichigoside F1
Catalog No: CFN91060

Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects. NI showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays. The dietary NI could prevent HFD-induced hepatic steatosis, possibly via interacting with HFD to activate Nrf2 nuclear translocation to maintain a redox status, thus regulating lipid metabolism genes expressions.

Nigranoic acid
Catalog No: CFN90253

Nigranoic acid is able to promote NO production and stimulate phosphorylation of ERK1/2 through Ca(2+) influx, further impact expression of BDNF and c-fos, may be benefit to enhance mental and intellectual functions; it has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation.Nigranoic acid exhibits significant inhibitory activity against HNE with the IC50 value of 3.77 μM, and six esters displayed considerable inhibitory effects on HNE with IC50 values in the range of 2.61-8.95 μM. Nigranoic acid shows activity in several anti-HIV reverse transcriptase and polymerase assays.

Nimbin
Catalog No: CFN97722

Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elicit a 50% inhibition of this steroid hydroxylase activity in the three insect species examined ranged from approximately 2 x 10(-5) to 1 x 10(-3). Nimbin also shows anti-feedant activity and toxicity against larvae of three species of Lepidoptera, Spodoptera littoralis (Boisd), Spodoptera frugiperda (FE Smith) and Helicoverpa armigera (Hübner) and nymphs of the locusts Schistocerca gregaria (Forskål) and Locusta migratoria (L).

Nimbolide
Catalog No: CFN91919

Nimbolide is a more potent antiproliferative and apoptosis inducing agent and offers promise as a candidate agent in multitargeted prevention and treatment of cancer; it can sensitize tumor cells to chemotherapeutic agents through interaction with IKK, leading to inhibition of NF-κB-regulated proteins. Nimbolide attenuates the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes. Nimbolide also has antibacterial potential.