Hot Products

Icariside D2
Catalog No: CFN96912

Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 uM, it induces apoptosis via alteration of expression of apoptosis-related proteins and decreased phosphorylation of AKT in HL-60 cells.

Icariside E5
Catalog No: CFN99373

Icariside E5 may have antioxidant property that strengthen the importance of peppers in the Mediterranean diet.

Icariside I
Catalog No: CFN92550

Icariside I is a metabolite product of Icariin.

Icaritin
Catalog No: CFN98527

Icaritin, a potent inhibitor of transcription factor SREBPs, which exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, hormone regulation, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.

Ikarisoside F
Catalog No: CFN90138

Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.

Ilexgenin A
Catalog No: CFN93149

Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth. It has anti-atherosclerotic activity, it shows reduction of atherosclerosis in apolipoprotein E deficient mice. Ilexgenin A is useful in the management of cardiovascular diseases in obesity, it inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner. Ilexgenin A could be regarded as a promising agent for the treatment of melanoma, it exerts anti-melanoma activity by arresting the cell cycle at G0/G1 and regulating IL-6 and TNF-α production.

Ilexoside K
Catalog No: CFN90994

Ilexoside K is a natural product from Ilex pubescens.

Ilexsaponin B2
Catalog No: CFN93153

Ilexsaponin B2 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, it is active against PDEI and PDE5A dose-dependently in vitro.

Ilicic acid
Catalog No: CFN98687

Reference standards.

Imperatorin
Catalog No: CFN98758

Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol); it is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. Imperatorin is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. Imperatorin has anticonvulsant, anti-inflammatory, anti-oxidant, neuroprotection, and anti-cancer effects, it also has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. Imperatorin dampens neuronal excitability by inhibiting voltage-gated Na + channels (VGSC), and blocks the HSP27 and HSP72 gene expression.