g-Strophanthin
g-Strophanthin can change the action potential, which is secondary events caused by the change of active Na+ transport.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Actions of G-strophanthin, adrenaline and acetylcholine on bullfrog ventricular muscle in the sodium-free lithium solution.[Reference:
WebLink]
METHODS AND RESULTS:
The actions of g-Strophanthin, adrenaline and acetylcholine on the action potential of bullfrog ventricular muscle were studied in the Na+ -free Li+ solution, in order to examine if these actions are associated with the change of active Na+ transport. The action of g-Strophanthin on the action potential, being observed in the Ringer solution, completely disappeared in the Na+-free Li+ solution. On the other hand, the actions of adrenaline and acetylcholine remained unchanged in the Na+ -free Li+ solution, except the hyperpolarizing action of adrenaline on the resting membrane.
CONCLUSIONS:
These results suggest that changes of the action potential by g-Strophanthin are secondary events caused by the change of active Na+ transport, whereas those by adrenaline and acetylcholine are primary events due to the change of membrane permeability.
Nature New Biology, 1971, 234(47):122-124.
Mutual exclusion of ATP, ADP and g-strophanthin binding to NaK-ATPase.[Reference:
WebLink]
METHODS AND RESULTS:
An investigation of the binding of the glycoside g-Strophanthin and of the substrate ATP to brain microsomal ATPase, described here, has shown that the number of binding sites for g-Strophanthin and ATP is identical and suggests that the glycosides inhibit the function of the enzyme by preventing the binding of ATP.The binding capacity for ATP and g-Strophanthin was determined on microsomal ATPase from ox brain prepared as described before7. The number of ATP-binding sites was measured by a rapid dialysis rate technique8,9, using 32P-ATP (Radiochemical Centre, Amersham) purified by chromatography9.
CONCLUSIONS:
To depress the hydrolysis of ATP, binding studies were carried out at 2° C in the presence of 10 mM EDTA to chelate any magnesium contaminating the preparations. No sodium or potassium was added.
