Voafinidine
Voafinidine is a natural product from Tabernaemontana divaricata.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Org Biomol Chem. 2003 Apr 21;1(8):1292-7.
Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata.[Pubmed:
12929658]
METHODS AND RESULTS:
The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, Voafinidine, voalenine and the new bisindole alkaloid, conophyllinine in addition to the previously known, biologically active bisindole, conophylline and its congener, conofoline. The structures of the new alkaloids were established by spectroscopic methods.
CONCLUSIONS:
The preparation and characterization of the corresponding quinones of the biologically active bisindoles are also described in relation to a structure-activity study of these compounds with respect to their action in stimulating insulin expression.
Natural Product Letters, 1996 , 8 (1) :49-53.
Voafinidine and Voalenine, Novel Indoles of the Aspidosperma-type from Tabernaemontana[Reference:
WebLink]
Novel indole alkaloids of the aspidosperma-type, viz., Voafinidine and voalenine were obtained in minor amounts from the leaf extract of Tabernaemontana divaricata (double flower variety). The structures of these alkaloids were elucidated by spectral methods.
